2006 Fiscal Year Final Research Report Summary
Analysis of Immunoregulation mechanism in recalcitrant allergic skin lesions and the development of new immunothrapy
| Project/Area Number |
16591108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Yokohama City University |
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Principal Investigator |
IKEAZAWA Zenro Yokohama City University, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (90046128)
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Yoshihiro Yokohama City University, School of Medicine, Assisiant, 医学部, 助手 (80381507)
NAKAZAWA Masatoshi Yokohama City University, School of Medicine, Assceiale_Professor, 医学部, 准教授 (20217699)
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| Project Period (FY) |
2004 – 2006
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| Keywords | Atopic dermatitis(AD) / Model mouse of AD / Endocrine disruptor, Tributyltin / Zinc deficiency food / Nerve growth factor / Semaphorin / Regulatory T cells / Supplement therapy |
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| Research Abstract |
1) Nerve growth factor (NGF) in the horny layer proteins taken fron the skin surface by stripping with sticky tape, correlated with skin symptoms of atopic dermatitis (AD), number of peripheral blood eosinophils and grade of itching, and also estimated as indicator of the efficacy of antiallergic drugs against itching of AD.
2) Several biomarkers reflecting symptoms of AD were detected by analysis of horny layer proteins, and the basis of development of new test system, which can detect rapidly and easily the skin function of AD, was established.
3) The effect of semaphorin, which is supposed to suppress the extension of peripheral nerve was examined in the experimental AD-like dermatitis.
4) The induction of oral tolerance were linked with the increase of FoxP3+CD25+T cells and its breakdown linked with the decrease of CD25+CD4+ regulatory T cells. Then, their clinical application has been studied.
5) The zinc deficiency induced and enhanced AD-like dermatitis in the experimental animal model mouse of AD. Then, the supplement effect of zinc on development of AD-like dermatitis has been studied.
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