2005 Fiscal Year Final Research Report Summary
Inhibition of cancer invasion and metastasis targeting heparanase
| Project/Area Number |
16591319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
NAOMOTO Yoshio Okayama University, Graduate School of Medicine. Dentistry and Pharmaceutical Sciences, Assistant professor, 大学院・医歯薬学総合研究科, 助教授 (00237190)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUOKA Junji Okayama University, Medical and Dental Hospital, Assistant, 医学部・歯学部附属病院, 助手 (30332795)
TANAKA Noriaki Okayama University, Graduate School of Medicine. Dentistry and Pharmaceutical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (10127566)
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| Project Period (FY) |
2004 – 2005
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| Keywords | heparanase / COX-2 / anaiogenesis |
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| Research Abstract |
Heparanase (HPA) is thought to play critical roles in invasion and metastasis of esophageal carcinomas. Cyclooxygenase-2 (COX-2) is a potent carcinogenic and angiogenic molecule that promotes tumor angiogenesis by prostaglandin E2 synthesis. We analyzed HPA and COX-2 expression in esophageal carcinoma, and found that HPA and COX-2 exhibited a similar expression pattern in esophageal tumor tissues. Moreover, expression of these molecules showed a significant correlation with high intratumoral microvessel density. In esophageal cancer cell lines transfected with the HPA-cDNA, upregulation of COX-2 mRNA and protein was detected by RT-PCR and western blotting. A COX-2 promoter assay showed that cyclic AMP responsible element (CRE), NFκB and NF-IL-6 sites in the COX-2 promoter were essential for the transcriptional activation induced by HPA. Next, we studied the relation of HPA and COX-2 using breast cancer and gastric cancer. Our results suggest that HPA and COX-2, both of which are thought to play independently critical roles in tumor progression and metastasis, are closely related.
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[Journal Article] COX-2 induction by heparanase in the progression of breast cancer.2006
Author(s)
Imada T, Matsuoka J, Nobuhisa T, Okawa T, Murata T, Tabuchi Y, Shirakawa Y, Ohra N, Gunduz M, Nagatsuka H, Umeoka T, Yamamoto Y, Nakajima M, Tanaka N, Naomoto Y.
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Journal Title
Int J Mol Med. Feb;17(2)
Pages: 221-228
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.2005
Author(s)
Okawa T, Naomoto Y, Nobuhisa T, Takaoka M, Motoki T, Shirakawa Y, Yamatsuji T, Inoue H, Ouchida M, Gunduz M, Nakajima M, Tanaka N.
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Journal Title
Clin Cancer Res. Nov 15 ; 11(22)
Pages: 7995-8005
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.2005
Author(s)
Noma K, Naomoto Y, Gunduz M, Matsuoka J, Yamatsuji T, Shirakawa Y, Nobuhisa T, Okawa T, Takaoka M, Tomono Y, Hiroyuki 0, Gunduz E, Tanaka N.
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Journal Title
Oncol Rep. Sep ; 14(3)
Pages: 645-650
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Emergence of nuclear heparanase induces differentiation of human mammary cancer cells.2005
Author(s)
Nobuhisa T, Naomoto Y, Takaoka M, Tabuchi Y, Ookawa K, Kitamoto D, Gunduz E, Gunduz M, Nagatsuka H, Haisa M, Matsuoka J, Nakajima M, Tanaka N.
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Journal Title
Biochem Biophys Res Commun. May 27 ; 331(l)
Pages: 175-180
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Heparanase expression correlates with malignant potential in human colon cncer.2005
Author(s)
Nobuhisa T, Naomoto Y, Ohkawa T, Takaoaka M, Ono R, Murata T, Gunduz M, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tsujigiwa H, Nagatsuka H, Nakajima M, Tanaka N.
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Journal Title
J Cancer Res Clin Oncol. Apr ; 131(4) Epub 2004 Dec 30
Pages: 229-237
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Localization o heparanase in esophageal cancer cells : respective roles in prognosis and differentiation.2004
Author(s)
OhkawaT, Naomoto Y, Takaoka M, Nobuhisa T, Noma K, Motoki T, Murata T, Uetsuka H, Kobayashi M, Shirakawa Y, Yamatsuji T, Matsubara N, Matsuoka J, Haisa M, Gunduz M, Tsujigiwa H, Nagatsuka H, Hosokawa M, Nakajima M, Tanaka N.
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Journal Title
Lab Invest. Oct ; 84(10)
Pages: 1289-1304
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Heparanase expression correlates with invasion and poor prognosis in gastric cancers.2003
Author(s)
Takaoaka M, Naomoto Y, Ohkawa T, Uetsuka H, Shirakawa Y, Uno F, Fujiwara T, Gunduz M, Nagatsuka H, Nakajima M, Tanaka N, Haisa M.
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Journal Title
Lab Invest. May ; 83(5)
Pages: 613-622
Description
「研究成果報告書概要(欧文)」より
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