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2006 Fiscal Year Final Research Report Summary

The influence of the splenic venous flow on the liver fibrosis and regeneration.

Research Project

Project/Area Number 16591363
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNippon Medical School

Principal Investigator

YOSHIDA Hiroshi  Nippon Medical School, Faculty of Medicine, Associate Professor, 医学部, 助教授 (60246999)

Co-Investigator(Kenkyū-buntansha) TAJIRI Takashi  Nippon Medical School, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (20163462)
AKIMARU Koho  Nippon Medical School, Faculty of Medicine, Professor, 医学部, 教授 (40142541)
MAMADA Yasuhiro  Nippon Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (40312061)
TANIAI Nobuhiko  Nippon Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (20287725)
Project Period (FY) 2004 – 2006
Keywordshemodynamics / liver fibrosis / liver regeneration / gene / spleen
Research Abstract

Objectives : The aim of this study is to prove the hemodynamic change in distribution of splenic venous flow in the liver, especially in the cirrhotic liver, and to reveal and evaluate a participation of splenic venous flow in regeneration or enlargement of the hepatic lobe.
Methods : We studied the distribution of splenic venous flow in the liver of patients with normal liver (NL group, n=14), chronic hepatitis (CH group, n=11), and liver cirrhosis (LC group, n=13) with the technique of scintiphotosplenoportography after percutaneous intrasplenic injection of Technetium-99m-diethylenetriaminepentaacetic asid-galactosyl-human serum albumin. The index of splenic venous flow volume per unit hepatocytes (V_<unit>) was calculated in each hepatic lobe. To compare V value of the left lobe (N Link) with that of the right lobe (V R_<unit>), predominant index of the left lobe (L/R index) was defined as L R index = V L_<unit>/ V R_<unit>.
Results : The median (interquartile range) of LI R index of LC group; 1.22 (1.06・1.70) was significantly higher than that of NL group; 0.83 (0.66-0.92), p<0.001 and CH group; 0.79 (0.69-0.92), p<0.001.
Conclusions : L/R index reflects the change of portal hemodynamics in cirrhotic liver and is useful for discrimination between noncirrhosis and cirrhosis. These results suggest that in the liver exposed to continuous damages, splenic venous blood promotes liver fibrosis in the right lobe and eventually flows more into the left lobe with milder fibrosis.

  • Research Products

    (10 results)

All 2005

All Journal Article (10 results)

  • [Journal Article] Long-term results of partial splenic artery embolization as supplemental treatment for hepatic encephalopathy associated with portal-systemic shunts2005

    • Author(s)
      Yoshida H, Mamada Y. et al.
    • Journal Title

      Am J Gastroenterol 100

      Pages: 43-47

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Collagen IV is a Predictor for Clinical Course with Malignant Obstructive Jaundice2005

    • Author(s)
      Mizuguchi Y, Yoshida H, et al.
    • Journal Title

      Hepatogastroenterol 52

      Pages: 672-677

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Arandomized control trial of bi-monthly versus bi-weekly endoscopic variceal ligation of esophageal varices2005

    • Author(s)
      Yoshida H, Mamada Y, et al.
    • Journal Title

      Am J Gastroenterol 100

      Pages: 2005-2009

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Changes in distribution of splenic venous flow in the patients with cirrhotic liver2005

    • Author(s)
      Mineta S, Yoshida H. et al.
    • Journal Title

      Hepatogastroenterol 52

      Pages: 1313-1319

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Fixation of the greater omentum for prevention of delayed gastric emptying after left-sided hepatectomy : A randomized controlled trial.2005

    • Author(s)
      Yoshida H, Mamada Y, et al.
    • Journal Title

      Hepatogastroenterol 52

      Pages: 1334-1337

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Short hairpin RNA modulates transforming growth factor Beta signaling in life-threatening liver failure in mice.2005

    • Author(s)
      Mizuguchi Y, Yoshida H, et al.
    • Journal Title

      Gastroenterology 129

      Pages: 1654-1662

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Long-term results of partial splenic artery embolization as supplemental treatment for hepatic encephalopathy associated with portal-systemic shunts.2005

    • Author(s)
      Yoshida H, Mamada Y, et al.
    • Journal Title

      Am J Gastroenterol 100

      Pages: 43-47

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Collagen IV is a Predictor for Clinical Course with Malignant Obstructive Jaundice.2005

    • Author(s)
      Mizuguchi Y, Yoshida H, et al.
    • Journal Title

      Hepatogastoroenterol 52

      Pages: 672-677

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A randomized control trial of bi-monthly versus bi-weekly endoscopic variceal ligation of esophageal varices2005

    • Author(s)
      Yoshida H, Mamada Y, et al.
    • Journal Title

      Am J Gastroenterol 100

      Pages: 2005-2009

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Changes in distribution of splenic venous flow in the patients with cirrhotic liver.2005

    • Author(s)
      Mineta S, Yoshida H, et al.
    • Journal Title

      Hepatogastroenterol 52

      Pages: 1313-1319

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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