2006 Fiscal Year Final Research Report Summary
The influence of the splenic venous flow on the liver fibrosis and regeneration.
| Project/Area Number |
16591363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
YOSHIDA Hiroshi Nippon Medical School, Faculty of Medicine, Associate Professor, 医学部, 助教授 (60246999)
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| Co-Investigator(Kenkyū-buntansha) |
TAJIRI Takashi Nippon Medical School, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (20163462)
AKIMARU Koho Nippon Medical School, Faculty of Medicine, Professor, 医学部, 教授 (40142541)
MAMADA Yasuhiro Nippon Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (40312061)
TANIAI Nobuhiko Nippon Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (20287725)
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| Project Period (FY) |
2004 – 2006
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| Keywords | hemodynamics / liver fibrosis / liver regeneration / gene / spleen |
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| Research Abstract |
Objectives : The aim of this study is to prove the hemodynamic change in distribution of splenic venous flow in the liver, especially in the cirrhotic liver, and to reveal and evaluate a participation of splenic venous flow in regeneration or enlargement of the hepatic lobe.
Methods : We studied the distribution of splenic venous flow in the liver of patients with normal liver (NL group, n=14), chronic hepatitis (CH group, n=11), and liver cirrhosis (LC group, n=13) with the technique of scintiphotosplenoportography after percutaneous intrasplenic injection of Technetium-99m-diethylenetriaminepentaacetic asid-galactosyl-human serum albumin. The index of splenic venous flow volume per unit hepatocytes (V_<unit>) was calculated in each hepatic lobe. To compare V value of the left lobe (N Link) with that of the right lobe (V R_<unit>), predominant index of the left lobe (L/R index) was defined as L R index = V L_<unit>/ V R_<unit>.
Results : The median (interquartile range) of LI R index of LC group; 1.22 (1.06・1.70) was significantly higher than that of NL group; 0.83 (0.66-0.92), p<0.001 and CH group; 0.79 (0.69-0.92), p<0.001.
Conclusions : L/R index reflects the change of portal hemodynamics in cirrhotic liver and is useful for discrimination between noncirrhosis and cirrhosis. These results suggest that in the liver exposed to continuous damages, splenic venous blood promotes liver fibrosis in the right lobe and eventually flows more into the left lobe with milder fibrosis.
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