2005 Fiscal Year Final Research Report Summary
Basic research for the antiepileptic mechanism of high-frequency electrical stimulation of subthalamicnucleus
| Project/Area Number |
16591425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
HASHIZUME Kiyotaka Asahikawa Medical College, Department of Neurosurgery, associate professor, 医学部, 講師 (00250580)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Tatsuya Asahikawa Medical College, Department of Neurosurgery, professor and chairman, 医学部, 教授 (20108715)
TAKEBAYASHI Seiji Asahikawa Medical College, Department of Neurosurgery, assistant, 医学部, 助手 (20312465)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Epilepsy / Deep Brain Stimulation / subthalamus / kainic acid / Experimental Epilepsy |
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| Research Abstract |
We investigated for the mechanism of antiepileptic effect of high-frequency electrical stimulation (HFS) of the subthalamic nucleus (STN).
Using male Wistar rats were implanted a guide cannula for kainic-acid injection into the left sensorimotor cortex and bipolar electrode into bilateral STN. Focal motor seizure was induced by kainic-acid injection via the cannula. When the animals showed epileptic status, HFS-STN was started. Seizure frequency was compared between on and off phase of HFS-STN. In the other animals, 14C-depxyglucose (DG) was intravenously injected to analyze change in cerebral glucose metabolism during HFS-STN.
The unilateral HFS-STN reduced seizure frequency to about 60 % in comparison to the control. Not only bilateral but also unilateral HFS-STN was effective against focal neocortical epilepsy. HFS-STN led to increase in glucose metabolism of ipsilateral superior colliculus and interpeduncular nucleus, and the decrease of striatum and substantia nigra. The metabolic change in the thalamus was also observed, but showed many variance. However, functional modulation of the thalamus may be important in the antiepileptic effect of HFS-STN.
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