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2005 Fiscal Year Final Research Report Summary

Candesartan Reduces Superoxide Production after Global Cerebral Ischemia

Research Project

Project/Area Number 16591428
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionAkita University

Principal Investigator

SUGAWARA Taku  Akita University, School of Medicine, Assistant Professor, 医学部, 講師 (80241660)

Co-Investigator(Kenkyū-buntansha) KINOUCHI Hiroyuki  Yamanashi University, School of Medicine, Professor, 大学院・医学工学総合研究部, 教授 (30241623)
Project Period (FY) 2004 – 2005
Keywordsglobal cerebral ischemia / superoxide / angiotensin receptor / angiotensin II
Research Abstract

Excessive superoxide production after cerebral ischemia is known to mediate neuronal injury. Angiotensin II type 1 receptor (AT1R) activation is recently identified as a source of superoxide, however, it has not been clear whether blockade of AT1R leads to reduction of superoxide and subsequent neuronal injury after ischemia. Normotensive rats received AT1R blocker, candesartan or vehicle and subjected to global cerebral ischemia. Candesartan rescued approximately 30% of the hippocampal CA1 neurons, whereas only 2% of neurons survived in vehicle-treated animals. There was significantly less superoxide production in these vulnerable neurons in candesartan-treated animals than in vehicle-treated animals. AT1R may play a pivotal role in superoxide production and subsequent injury in the vulnerable neurons after global cerebral ischemia.

  • Research Products

    (4 results)

All 2005

All Journal Article (4 results)

  • [Journal Article] Candesartan reduces superoxide production after global cerebral ischemia2005

    • Author(s)
      Sugawara T et al.
    • Journal Title

      Neuroreport 16.4

      Pages: 325-328

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Akt/Bad signaling and motor neuron survival after spinal cord injury2005

    • Author(s)
      Yu F, Sugawara T et al.
    • Journal Title

      Neurobiol Dis 20

      Pages: 491-499

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and after transient global cerebral ischemia2005

    • Author(s)
      Narasimhan P, Sugawara T et al.
    • Journal Title

      J Neurochem 93

      Pages: 351-358

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Candesartan reduces superoxide production after global cerebral ischemia2005

    • Author(s)
      Sugawara T et al.
    • Journal Title

      Neuroreport 16

      Pages: 325-328

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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