2005 Fiscal Year Final Research Report Summary

The relationship of prostaglandin D synthesis and pathogenesis of rheumatoid arthritis.

Research Project

Project/Area Number	16591485
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Orthopaedic surgery
Research Institution	SHIGA UNIVERSITY OF MEDICAL SCIENCE
Principal Investigator	EGUCHI Yutaka Shiga University of Medical Science, Professor, 医学部, 教授 (00263054)
Co-Investigator(Kenkyū-buntansha)	URADE Yoshihiro Osaka Bioscience Institute, Director, 第2研究部, 研究部長 (10201360) EGUCHI Naomi Osaka Bioscience Institute, Associate Director, 第2研究部, 研究副部長 (10250086) KAWASAKI Taku Shiga University of Medical Science, Assistant, 医学部, 助手 (50359775)
Project Period (FY)	2004 – 2005
Keywords	IgM-RF / Osteoarthritis / Immune histochemistry / Synovia / Prostaglandin
Research Abstract	We firstly demonstrated that serum levels of L-PGDS was increased in patients with rheumatoid arthritis(RA) compared with osteoarthritis(OA) patients and normal control subject. Whereas, knee synovial levels of L-PGDS was significantly increased in RA patients than OA patients. Further, the synovial L-PGDS levels was significantly correlated with titer of IgM-RF. Therefore, the serum level of L-PGDS may be useful for the diagnosis of RA and the marker of the therapeutic target.