2005 Fiscal Year Final Research Report Summary
Network of the spinally mediated analgesia and analgesic interaction between different agents
| Project/Area Number |
16591527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NISHIYAMA Tomoki The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 (70272581)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Spinal cord / Pain / Rat / Thermal / Inflammation / Surgery |
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| Research Abstract |
Edaravone, sarpogrelate, celecoxib, and propofol could not give 50% effective doses (ED50) because they did not show any dose-dependent analgesic effects in the tail flick test. However, these agents could give ED50 in the formalin test. Bacrofen, morphine, neostigumine, and carbachol had dose-dependent analgesia to give ED50 both in the tail flick test and formalin test.
Regarding the interaction study in the tail flick test, YM872 and bacrofen, YM872 and neostigmine, and serotonin and bacrofen showed additive effects, bacrofen and AP-5, clonidine or bupivacaine showed inhibitory effects, but other combinations tested had synergistic effects. In the phase 1 of the formalin test, midazolam and neostigmine showed additive effects, epibatidine and bacrofen had an inhibitory interaction, but other combinations showed synergistic effects. In the phase 2 of the formalin test, all the combinations had synergistic analgesic effects.
Incision of the plantar increased allodynia tested by the Von Frey Filaments, decreased the load on the plantar tested by the Incapacitance Tester, and decreased latency of the escape reaction against thermal stimuli for 7 days. Intrathecal administration of morphine inhibited allodynia by Von Frey filaments but without dose-dependency, did not inhibit decreased load by the Incapacitance Tester, and increased latency of the escape reaction against thermal stimuli. Thus, intrathecal morphine had different effects on different stimuli after surgery.
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Research Products
(9 results)
