2006 Fiscal Year Final Research Report Summary
Evaluation of mechanical ventilation using a bigeminal breathing pattern during a marathon on the oxygen uptake efficiency and lung protective ventilation.
| Project/Area Number |
16591539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tottori University |
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Principal Investigator |
OKAZAKI Naoto Tottori University, Faculty of Medicine, Research Associate, 医学部, 助手 (30032204)
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| Project Period (FY) |
2004 – 2006
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| Keywords | marathoner's breathing pattern / protective ventilation / pulmonary vascular resistance / low stretch ventilation / ventilator-induced lung injury / isolated-perfused lung model / lung wet to dry ratio / gas redistribution phenomenon |
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| Research Abstract |
The 2-2 breathing during a marathon enables carbon dioxide elimination and oxygen uptake at a high metabolic rate over an extended period of time. Furthermore, from the evidence that the load by marathon does not cause the pulmonary physiological unbalance, this ventilation method can expect greater protective effects on the ventilator-induced lung injury in comparison with the small tidal volume ventilation method. So, the pulmonary oxygenation efficiency and pulmonary protective effects of the ventilation method using the marathoner's breath pattern (MBV) were studied in animal experiments using rabbits.
The time distribution (sec.) of one breath cycle is inspiration of 0.3, pause of 0.2, inspiration of 0.3, pause of 0.2, expiration of 0.3, pause of 0.2, and expiration of 0.5.
The following results were observed :
1) Although the MBV provides small-volume ventilation in both tidal volume and minute volume, there was not any problem in the efficiency of oxygen uptake and carbon dioxide elimination.
2) The airway pressure was kept low.
3) The effects were due to the gas redistribution phenomenon which occurred during the three pause periods.
4) This device can set PEEP (positive end-expiratory pressure) in two steps, so further effects can be observed.
5) In comparison with conventional ventilation method, the MBV method showed a lung protective effect by suppressing the wet-to-dry ratio.
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