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2005 Fiscal Year Final Research Report Summary

Prevalence of symptoms of andropause in Japanese healthy men

Research Project

Project/Area Number 16591607
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionSapporo Medical University

Principal Investigator

TAKAHASHI Atsushi  Sapporo Medical University, School of Medicine, Assistant Professor, 医学部, 講師 (20274946)

Co-Investigator(Kenkyū-buntansha) ITOH Naoki  Sapporo Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (60193504)
MASUMORI Naoya  Sapporo Medical University, School of Medicine, Assistant Professor, 医学部, 講師 (20295356)
Project Period (FY) 2004 – 2005
Keywordsandropause / aging society / AMS rating scale / testosterone / free testosterone / bioavailable testosterone
Research Abstract

<Objective> : The aim of this study was to clarify the prevalence of aging male's symptoms and their relation to the serum testosterone levels in healthy Japanese males.
<Subjects and Methods> : For this study, 206 males aged from 20 to 77 years who visited to hospitals for health checkups were recruited after giving informed consent. Aging males' symptoms were evaluated by Heinemann's Aging Males' Symptoms rating scale (AMS). Serum total and free testosterone (T) were measured using commercially available radioimmunoassay kits. Calculated bioavailable testosterone (CBT) was estimated by total T, albumin and sex hormone-binding globulin (SHBG). This study was approved by the institutional review board of our hospital.
<Results> : The percentages of subjects who had moderate or severe symptoms of AMS were 0% in 20s, 19.4% in 30s, 17.6% in 40s, 30.4% in 50s, 46.5% in 60s and 60% in 70s. The total AMS score was significantly correlated with serum free T (r=-0.236, P<0.001). In particular, serum free T was significantly correlated with the somatic domain (r=-0.181, p<0.01) and sexual domain (r=-0.351, p<0.001) of AMS. No correlation was shown between total T and the total AMS score and any subscale. The psychological subscale of AMS did not have a correlation with any androgen. Of men in their 40s, 5.9% had a low free T level (less than 8.5pg/ml) and symptoms of aging males (37 or more in AMS rating scale), as did 13.0% in their 50s, 25.6% in their 60s and 26.6% in their 70s.
<Conclusions> : About one third to half of healthy Japanese males had aging male's symptoms. Serum free T is suspected to be the most appropriate value to predict aging males' symptoms in the general population.

  • Research Products

    (12 results)

All 2006 2005 2004

All Journal Article (12 results)

  • [Journal Article] LOH(late-onset hypogonadism : 男性更年期障害)2006

    • Author(s)
      伊藤直樹
    • Journal Title

      日本臨床 64(増4)

      Pages: 499-503

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 男性更年期障害の概念と社会的問題2005

    • Author(s)
      伊藤直樹
    • Journal Title

      Pharma Media 23

      Pages: 17-20

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] テストステロン2005

    • Author(s)
      伊藤直樹
    • Journal Title

      Medicina 42

      Pages: 349-350

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] General concept of andropause2005

    • Author(s)
      Naoki Itoh
    • Journal Title

      Pharma Media 23(5)

      Pages: 17-20

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Testosterone2005

    • Author(s)
      Naoki Itoh
    • Journal Title

      Medicina 42(12)

      Pages: 349-350

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] LOH (late-onset hypogonadism)2005

    • Author(s)
      Naoki Itoh
    • Journal Title

      Nipponrinsho 64(Suppl 4)

      Pages: 499-503

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 男性更年期障害で用いる質問紙 : その有用性と限界2004

    • Author(s)
      伊藤直樹
    • Journal Title

      Urology View 2

      Pages: 56-62

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 男性更年期障害の診断基準と治療のあり方 : 本邦と海外2004

    • Author(s)
      伊藤直樹
    • Journal Title

      泌尿器外科 17

      Pages: 1018-1021

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 男性更年期障害に対する男性ホルモン補充療法2004

    • Author(s)
      伊藤直樹
    • Journal Title

      Geriatric Medicine 42

      Pages: 1151-1156

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Questionnaires for the diagnosis of andropause2004

    • Author(s)
      Naoki Itoh
    • Journal Title

      Urology View 2(1)

      Pages: 56-62

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Androgen replacement therapy of the hypogonadal men in Japan and other countries2004

    • Author(s)
      Naoki Itoh
    • Journal Title

      Japanese Journal of Urological Surgery 17(9)

      Pages: 1018-1021

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Androgen replacement therapy2004

    • Author(s)
      Naoki Itoh
    • Journal Title

      Geriatric Medicine 42

      Pages: 1151-1156

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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