2005 Fiscal Year Final Research Report Summary
Epithelial transformation by stroma transplant in urogenital organs
| Project/Area Number |
16591631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Aichi Cancer Center (Research Institute) |
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Principal Investigator |
HAYASHI Norio Aichi Cancer Center (Research Institute), Division of Molecular Pathology, Researcher, 分子病態学部, 研究員 (70198852)
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| Co-Investigator(Kenkyū-buntansha) |
TAGUCHI Osamu Aichi Cancer Center (Research Institute), Division of Molecular Pathology, Section head, 分子病態学部, 室長 (00142167)
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| Project Period (FY) |
2004 – 2005
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| Keywords | bladder / prostate / uters / storma / epithelium / mouse / nude mouse / rat |
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| Research Abstract |
Squamous hyperplasia of bladder epithelium was induced when stromal tissues of urogenital sinus were transplanted near the bladder epithelium of male mice. In addition, prostate-like glandular structure was sometimes observed in the bladder of the mice. When the section of glandular epithelial cells was stained with anti-prostate specific antibody, positive reaction was observed. These results show that the part of bladder epithelium of in situ induced in urogenital sinus stroma shows morphologically functionally changing in the prostate epithelium. As a similar experiment, it was confirmed that the epithelium of uterus changed to that of vagina, when the stroma of urogenital sinus was transplanted into uterine cavity of female mice before sexual maturation. And, the hyperplasia of the mouse prostate epithelium was able to be induced, when rat urogenital sinus stroma was transplanted in prostate of nude mice. The derivation of the tissues was distinguished by the antibody which peculiarly reacted with rat or mouse.
The bladder epithelium showed the hyperplasia, when the stroma of proventriculus was transplanted in the bladder. Furthermore, some of epithelium took the small gland structure that was not proventriculus and was not bladder too. As for this phenomenon, it is supposed that confusion occurred by a lot of information being given bladder epithelium at the same time from transplanted and original bladder stromal tissues. Or it is thought that an abnormal hyperplasia is caused by stimulation for bladder epithelium from stroma of the genetically different organs.
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[Journal Article] Immunity against mouse thymus-leukemia antigen (TL) protects against development of lymphomas induced by a chemical carcinogen, N-butyl-N-nitrosourea.2004
Author(s)
Tsujimura K, Obata Y, Matsudaira Y, Ozeki S, Taguchi O, Nishida K, Okanami Y, Akatsuka Y, Kuzushima K, Takahashi T
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Journal Title
Cancer Sci. 95
Pages: 914-919
Description
「研究成果報告書概要(欧文)」より
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