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2005 Fiscal Year Final Research Report Summary

Analysis on the polymorphism of genotype of enzymes for detoxication in patients with infertility

Research Project

Project/Area Number 16591646
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNiigata University

Principal Investigator

TAKAKUWA Koichi  Niigata University, Institute of Medicine and Dentistry, Associate Professor, 医歯学系, 助教授 (80187939)

Co-Investigator(Kenkyū-buntansha) ISHII Keisuke  Niigata University, Medical and Dental Hospital, Assistant, 医歯学総合病院, 助手 (40361927)
Project Period (FY) 2004 – 2005
Keywordsinfertility / Enzymes for detoxication / Gene polymorphism / Cyp1A1 / GSTs
Research Abstract

The etiology of the recurrent miscarriage has not been fully elucidated, and the relationship between the genotype of enzymes for detoxication and recurrent miscarrage has recently been noted. Thus, the genotypes of enzymes for detoxication, such as cytchrome P450 (CYPIAI), glutathione-S-transferase-pai (GST-pai), GST-my, GST-theta, were analyzed in patients with infertility, who had experienced recurrent miscarriages by means of polymerase-chain reaction- restrication fragment length polymorphism (PCR-RFLP) method. The patients were sent out the questionnaires concernig history of smoking, or alchol intake. So far, 44 patients were enrolled into the study, and 30 normal fertile women, who had never experienced abortions, were also enrolled into this study.
The frequency of each genotype of the enzymes was compared between the patient population and control group. The significant difference was not observed concerning CYPIAI, glutathione-S-transferase-pai (GST-pai), GST my. However, the frequency of la genotype of GST-pai was signinficantly higher in patients group compared with control population. In order to obtain definite conclusion, further investigation is considered to be mandatory, increasing the number of the patients and control population

  • Research Products

    (8 results)

All 2006 2005

All Journal Article (8 results)

  • [Journal Article] Molecular genetic studies on the compatibility of HLA-class II alleles in patients with unexplained reucrrent miscarriage in the Japanese population2006

    • Author(s)
      K.Takakuwa, et al.
    • Journal Title

      Clinical Immunology 118

      Pages: 101-107

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with husband's mononuclear cells2006

    • Author(s)
      T.Yokoo, K.Takakuwa, et al.
    • Journal Title

      Fertility and Sterility (In press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Studies on the human leukocyte antigens in patients with polycystic ovary syndrome in a Japanese population. -Possible susceptibility of HLA-A11 and - DRB1*0403 to PCOS-.2006

    • Author(s)
      M.Kibe, K.Takakuwa, et al.
    • Journal Title

      American Journal of Reproductive Immunology 55

      Pages: 301-306

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Alteration of TH1 and TH2 cells by intracellular cytokine detection in patients with unexplained recurrent abortion before and after immunotherapy with husband's mononuclear cells2006

    • Author(s)
      T.Yokoo, K.Takakuwa, et al.
    • Journal Title

      Fertility and Sterility (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Studies on the human leukocyte antigens in patients with polycystic ovary syndrome in a Japanese population. -Possible susceptibility of HLA-A11 and -DRB1^*0403 to patient population with polycystic ovary syndrome.2006

    • Author(s)
      M.Kibe, K.Takakuwa, et al.
    • Journal Title

      American Journal of Reproductive Immunology 55

      Pages: 301-306

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Compatibility of HLA-A and -B antigens in patients with unexplained recurrent abortion2005

    • Author(s)
      T.Yokoo, K.Takakuwa, et al.
    • Journal Title

      Acta Medica et Biologica 53

      Pages: 43-49

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] わかりやすい免疫疾患「生殖免疫 マイクロキメリズムと疾患」2005

    • Author(s)
      高桑好一
    • Journal Title

      日本医師会雑誌 134

      Pages: S96-S97

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Reproductive Immunology, Microchimerism and disease2005

    • Author(s)
      K.Takakuwa
    • Journal Title

      The Journal of the Japan Medical Association (in Japanese) 134

      Pages: S96-S97

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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