2007 Fiscal Year Final Research Report Summary
Effects of various cytokines on the fimctions of trophblasts in the placenta in complicated pregnancies
| Project/Area Number |
16591681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | International University of Health and Welfare (2005-2007)
Dokkyo Medical University (2004) |
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Principal Investigator |
HAYASHI Masatoshi International University of Health and Welfare, Department of Obstetrics and Gynecology, Professor (90164962)
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| Co-Investigator(Kenkyū-buntansha) |
OHKURA Takeyoshi Dokkyo Medical University Koshigaya Hospital, Department of Obstetrics and Gynecology, Professor (80092394)
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| Project Period (FY) |
2004 – 2007
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| Keywords | preeclampsia / normal pregnancies / M-CSF / GM-CSF / IL-6 / TNF-a / placenta / amniotic fluid |
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| Research Abstract |
Serum levels of tumor necrosis factor-α (TNF-α), Th1 cytokine, were higher in preeclampsia than in normal pregnancies. However, serum levels of interleukin-6 (IL-6), Th2 cytokine, and both TNF-α and IL-6 levels in the placenta did not differ between the two groups. These findings suggest that serum TNF-α is involved in the pathophysiology of preeclampsia but that in the placenta neither TNF-α nor IL-6 play an important role. Amniotic fluid IL-6 levels did not differ between the two groups, suggesting that IL-6 is not involved in the pathophysiology of this condition. Significantly lower birth weights of neonates were seen in preeclampsia compared with those in normal pregnancies. Thus, placental dysfunction might be occurred in preeclampsia. However, IL-6 did not play an important role in the placental dysfunction. Amniotic fluid macrophage colony-stimulating factor (M-CSF) concentrations were significantly higher in women who delivered small-for-gestational-age (SGA) infants than in women who delivered appropriate-for-gestational-age (AGA) infants. Excessive concentrations of M-CSF in amniotic fluid via amniotic membranes may be highly related to immunological abnormalities contributing to low birth weight of neonates. There was no significant increase in granulocyte-macrophage colony-stimulating factor (GM-CSF) levels in amniotic fluid during labor compared to that before the onset of labor. Thus, GM-CSF in amniotic fluid may not promote the onset of labor at term and/or term labor contributing to subsequent delivery may not induce the production and secretion of GM-CSF into amniotic cavity. Amniotic fluid M-CSF concentrations were significantly higher in term gravidas than in women at 17 weeks of gestation. This finding suggests that elevated levels of M-CSF in amniotic fluid have an important immunological function in the maintenance of pregnancy and fetal growth.
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[Journal Article] Tumor necrosis factor-a in the placenta is not elevated in pre-eclamptic patients despite its elevation in peripheral blood2005
Author(s)
Hayashi, M, Ueda, Y, Yamaguchi, T, Sohma, R, Shibazaki, M, Ohkura, T, Inaba, N
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Journal Title
Am J Reprod Immunol 53(3)
Pages: 113-119
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 妊娠中毒症および正常血圧IUGR妊娠での羊水中macrophage colony-stimulatingfactorの動態2004
Author(s)
林, 雅敏, 相馬, 良一, 堀中, 奈奈, 杉山, 紀子, 濱田, 佳伸, 大藏, 健義
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Journal Title
日本妊娠中毒症学会雑志 12
Pages: 151-152
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 妊娠高血圧症候群での胎盤組織内および血液中でのIL-6, TNF-α, sTNF-R1の動態2007
Author(s)
中島, 瑠美子, 五來, 逸雄, 田中, 躍, 提坂, 敏昭, 林, 雅敏
Organizer
第114回日本産科婦人科学会関東連合地方部会
Place of Presentation
前橋市
Year and Date
2007-10-14
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 妊娠高血圧症候群患者の胎盤組織内および末梢血中でのIL-4, IL-6, IL-10の動態2006
Author(s)
林, 雅敏, 矢追, 正幸, 星本, 和倫, 濱田, 佳伸, 深澤, 一雄, 大藏, 健義, 稲葉, 憲之
Organizer
第58回日本産科婦人科学会
Place of Presentation
横浜市
Year and Date
2006-04-24
Description
「研究成果報告書概要(欧文)」より
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[Presentation] necrosis factor-a in the placenta is not elevated in preeclamptic patients despite its elevation in peripheral blood2005
Author(s)
Hayashi, M, Sohma, R, Kataoka, S, Horinaka, N, Ohkura, T, Tumor
Organizer
Asian Pacific Congress on Controversies in Obstetrics, Gynecology and Infertility
Place of Presentation
Bangkok, Thailand
Year and Date
20051125-28
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 妊娠中毒症患者の胎盤組織内および末梢血中でのM-CSF, GM-CSF, TNF-α, TNF-R1の動態2004
Author(s)
林, 雅敏, 星本, 和倫, 堀中, 奈奈, 安藤, 昌守, 濱田, 佳伸, 友部, 勝実, 矢追, 正幸, 堀中, 俊孝, 榎本, 英夫, 深澤, 一雄, 大藏, 健義, 稲葉, 憲之
Organizer
第56回日本産科婦人科学会
Place of Presentation
東京都
Year and Date
2004-04-13
Description
「研究成果報告書概要(欧文)」より
