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2005 Fiscal Year Final Research Report Summary

Analysis of Th1, Th2, Tc1 and Tc2 cells of patients with otolaryngological diseases.

Research Project

Project/Area Number 16591697
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionYamagata University

Principal Investigator

OHTA Nobuo  Yamagata University, Otolaryngology, Lecturer, 医学部, 講師 (20282212)

Project Period (FY) 2004 – 2005
KeywordsTh1 / Th2 / Tc1 / Tc2 / allergic rhinitis
Research Abstract

Cytokines are important regulatory mediators secreted by T cells and other immunoactive cells. Based on the cytokine synthesis patterns, CD4 T cells can often be classified into at least two populations with different immune regulatory functions. Th1 cells, producing IL-2 and IFN-γ, are often associated with cell-mediated immune responses such as DTH, whereas Th2 cells, secreting IL-4, IL-5, IL-13, usually provide B cell help and enhance allergic reactions. Naive CD8 T cells, similar to CD4 T cells, can differentiate into at least two subsets of cytolytic effector cells with distinct cytokine patterns. Tc1 cells secrete a Th1-like cytokine pattern, including IL-2 and IFN-γ^^~. Tc2 cells produce Th2 cytokines, including IL-4, IL-5 and Il-10. There is increasing evidence that Th1/Th2 and Tc1/Tc2 cytokine imbalance has been of pathogenetic importance in various diseases, such as allergic and autoimmune diseases. The present review article focuses on the evidence that the imbalance of Th1/Th2 and Tc1/Tc2 cytokines play important role in various otolaryngological diseases, such as Kimura's disease, Wegener's granulomatosism, acute perceptive hearing loss and Menier's disease. It is concluded that the predominance of Th1 and Th2 and Tc1 and Tc2 cells might contribute to the mechanism in pathogenesis of these otolaryngological diseases.

  • Research Products

    (6 results)

All 2005

All Journal Article (6 results)

  • [Journal Article] Th1, Th2, Tc1 and Tc2 cells of patients with allergic rhinitis.2005

    • Author(s)
      Ohta N他
    • Journal Title

      Allergy Clinical Immunol Int. 1

      Pages: 252

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Th1 and Th2 CD4 and Tc1 and Tc2 CD8 T cells of patients with Wegener's granulomatosis.2005

    • Author(s)
      Ohta N他
    • Journal Title

      Allergy Clinical Immunol Int. 1

      Pages: 290

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Analysis of Th1, Th2, Tc1 and Tc2 cells of patients with allergic rhinitis.2005

    • Author(s)
      Ohta N他
    • Journal Title

      Clin Exp Allergy 5

      Pages: 68-71

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Th1, Th2, Tc1 and Tc2 cells of patients with allergic rhinitis.2005

    • Author(s)
      Ohta N, et al.
    • Journal Title

      Allergy Clinical Immunol Int. 1

      Pages: 252

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Th1 and Th2 CD4 and Tc1 and Tc2 CD8 T cells of patients with Wegener's granulomatosis.2005

    • Author(s)
      Ohta N, et al.
    • Journal Title

      Allergy Clinical Immunol Int. 1

      Pages: 290

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Analysis of Th1, Th2, Tc1 and Tc2 cells of patients with allergic rhinitis.2005

    • Author(s)
      Ohta N, et al.
    • Journal Title

      Clin Exp All 5

      Pages: 68-71

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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