2005 Fiscal Year Final Research Report Summary
Carcinogenesis of Human Papilloma Virus related Head and Neck Carcinoma
| Project/Area Number |
16591704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
MINETA Hiroyuki Hamamatsu University School of Medicine, Professor, 医学部, 教授 (40190714)
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| Co-Investigator(Kenkyū-buntansha) |
MINERA Katsuyoshi Hamamatsu University, Hospital, Associate Professor, 医学部附属病院, 助教授 (20173974)
TAKEBAYASHI Satoru Hamamatsu University, Hospital, Assistant Professor, 医学部附属病院, 講師 (70283356)
SASAKI Yutaka Hamamatsu University, Hospital, Instructor, 医学部附属病院, 助手 (40324363)
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| Project Period (FY) |
2004 – 2005
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| Keywords | HPV / carcinogenesis / head and neck cancer |
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| Research Abstract |
Human Papilloma Virus (HPV) is closed related with head and neck squamous cell carcinaomas(HNSCC). We reported the incidence of HPV among HNSCCs using in situ hybridization method, and showed the highest one is oropharyngeal cancer.
The HPV type consisted of malignant type (16,18,31 and so on) and benign type (6,11,56 and so on). Among HNSCC we detected the highest is HPV 16.
HPV E2 which is destructed is not able to inhibit E6 and E7 genes, so E6 and E7 combines p53 and Rb genes respectively
Now we research HPV E2 gene transfect into Hella and Caski cell lines.
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