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2006 Fiscal Year Final Research Report Summary

Ischemic neuronal dysfunction in the vestibular nucleus and plasticity

Research Project

Project/Area Number 16591723
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNara Medical University

Principal Investigator

YAMANAKA Toshiaki  Nara Medical University, School of Medicine, Senior Lecturer, 医学部, 講師 (90271204)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Hideyuki  Nara Medical University, School of Medicine, Lecturer, 医学部, 助手 (80316075)
MURAI Takayuki  Nara Medical University, School of Medicine, Lecturer, 医学部, 助手 (20326325)
Project Period (FY) 2004 – 2006
Keywordsvestibular nucleus / hypoxic depolarization / plasticity / glutamate
Research Abstract

Brainstem hypoxia due to vertebrobasilar insufficiency is well known to induce vertigo which is caused by an imbalance between the bilateral vestibular nuclei. Electrophysiological studies have been performed to examine the effects of hypoxia on medial vestibular nucleus (MVN).
We previously figured out that the enhancement of neuronal activity (Post Hypoxic Potentiation : PHP) take place in medial vestibular nucleus (MVN) after hypoxia which cause hypoxic depolarization (HD) followed by neuronal dysfunction. In this study, we examined the role of glutamate in the PHP of MVN neuron. Single neuronal activities of MVN in α-chloralose-anesthetized cats were recorded extracellularly with a glass-insulated silver wire microelectrode attached along a several-barreled micropipette. Each barrel was filled with DNQX, non-NMDA glutamate receptor antagonist and MK-801, NMDA glutamate receptor antagonist. These chemicals were applied microiontophoretically to the immediate vicinity of the target neurons. Neuronal firings decreased by 5% O_2 for 3 min, recovered gradually after the termination of hypoxia and showed the increase in firings more than 150% of control about 30 min after hypoxia. This PHP was dependent on the activation of HD and was inhibited by iontophoretic application of DNQX or MK-801 during hypoxia. These results suggest that NMDA and non-NMDA glutamate receptor in MVN is implicated in the production of PHP.

  • Research Products

    (6 results)

All 2006

All Journal Article (6 results)

  • [Journal Article] 難治性BPPVの治療 -対応と処置-2006

    • Author(s)
      山中敏彰
    • Journal Title

      Equilibrium Research 65

      Pages: 144-155

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 後半規管型BPPVの病態と臨床像2006

    • Author(s)
      山中敏彰
    • Journal Title

      JOHNS 22

      Pages: 11-18

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 起立性めまい症に対する血圧と椎骨動脈血流動態の関与2006

    • Author(s)
      澤井八千代, 山中敏彰
    • Journal Title

      頭頚部自律神経 20

      Pages: 61-64

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Treatment for Intractable BPPV2006

    • Author(s)
      Yamanaka.T et al.
    • Journal Title

      Equilibrium Research 65

      Pages: 144-155

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clinical feature of posterior semicircular canal BPPV2006

    • Author(s)
      Yamanaka.T et al.
    • Journal Title

      JOHNS 22

      Pages: 11-18

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hemodynamics of vertebral artery in the orthostatic vertigo2006

    • Author(s)
      Sawai Y, Yamanaka.T et al.
    • Journal Title

      Neuroscience of Oto-rhino-laryngology 20

      Pages: 61-64

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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