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2005 Fiscal Year Final Research Report Summary

Molecular biological analysis and treatment for diabetic retinopathy

Research Project

Project/Area Number 16591774
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKansai Medical University

Principal Investigator

OGATA Nahoko  Kansai Medical University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (60204062)

Co-Investigator(Kenkyū-buntansha) WADA Mitsumasa  Kansai Medical University, Faculty of Medicine, Instructor, 医学部, 助手 (40333215)
Project Period (FY) 2004 – 2005
Keywordsdiabetic retinopathy / angiogenesis / PEDF / VEGF / platelet-derived microparticles / monocyte-derived microparticles
Research Abstract

Diabetic retinopathy is a major cause of blindness in adults. We investigate the retinal changes in SDT (Spontaneously Diabetic Torii) rats, a model of type 2 diabetic mellitus, and the molecular mechanisms controlling the diabetic retinopathy. Propliferative tissues that are similar to human proliferative diabetic retinopathy (PDR) are found in eyes of some of the SDT rats. However, SDT rats have a low incidence of retinal neovascularization and poor development of retinal non-perfused areas. Expression of vascular endothelial growth factor (VEGF), a major angiogenic stimulator, and pigment epithelium-derived factor (PEDF), an angiogenic inhibitor, were both increased in the retina of SDT rats. PEDF inhibited the VEGF-induced leukostasis. Thus, the high levels of PEDF in the retina of SDT rats may contribute to the low incidence of neovascular formation and absence of non-perfused areas that did not match the typical diabetic retinopathy in humans. In human PDR tissues, VEGF and PEDF were both strongly expressed, but the distribution was different.
Platelet-derived microparticles (PDMPs) stimulate the coagulation cascade and increase leukocyte and endothelial cell adhesions, and monocytes-derived microparticles (MDMPs) are released from activated monocytes and enhance the procoagulant activity. These activities are key events in the development of diabetic retinopathy. PDMPs and MDMPs are correlated with each other and also correlated with activated platelet (CD62P and CD63) and adhesion molecules (P-selectin and ICAM-1). PDMPs and MDMPs are increased according to the progression of diabetic retinopathy. Therefore, increased levels of MDMPs and PDMPs may accelerate the progression of diabetic retinopathy.

  • Research Products

    (25 results)

All 2006 2005 2004

All Journal Article (24 results) Book (1 results)

  • [Journal Article] Pars plana vitrectomy with removal of postrior hyaloid face in treatment of refractory diabetic macular edema resistant to triamcinolone acetonide2006

    • Author(s)
      Higuchi A, Ogata N, Jo N, Wada M, Matsumura M
    • Journal Title

      Japanese Journal of Ophthalmology 50 (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Elevation of monocyte-derived microparticles in patients with diabetic retinopathy2006

    • Author(s)
      Ogata N, Nomura S, Shouzu A, Imaizumi M, Arichi M, Matsumura M
    • Journal Title

      Diabetes Research and Clinical Practice 69 (in press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of pigment epithelium-derived factor and vascular endothelial growth factor in fibrovascular membranes from eyes with proliferative diabetic retinopathy2006

    • Author(s)
      Matsuoka M, Ogata N, Minamino K, Matsumura M
    • Journal Title

      Japanese Joumal of Ophthalmology 50

      Pages: 116-120

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes2006

    • Author(s)
      Matsuoka M, Ogata N, Minamino K, Higuchi A, Matsumura M
    • Journal Title

      Experimental Eye Research 82

      Pages: 172-178

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Pars plana vitrectomy with removal of posterior hyaloid face in treatment of refractory diabetic macular edema resistant to triamcinolone acetonide2006

    • Author(s)
      Higuchi A, Ogata N, Jo N, Wada M, Matsumura M
    • Journal Title

      Japanese Journal of Ophthalmology 50(in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Elevation of monocyte-derived microparticles in patients with diabetic retinopathy.2006

    • Author(s)
      Ogata N, Nomura S, Shouzu A, Imaizumi M, Arichi M, Matsumura M
    • Journal Title

      Diabetes Research and Clinical Practice 69(in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of pigment epithelium-derived factor and vascular endothelial growth factor in fibrovascular membranes from eyes with proliferative diabetic retinopathy.2006

    • Author(s)
      Matsuoka M, Ogata N, Minamino K, Matsumura M
    • Journal Title

      Japanese Journal of Ophthalmology 50

      Pages: 116-120

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes.2006

    • Author(s)
      Matsuoka M, Ogata N, Minamino K, Higuchi A, Matsumura M
    • Journal Title

      Experimental Eye Research 82

      Pages: 172-178

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Trans-Tenon's retrobulbare injection of triamcinolone acetonide for diffuse diabetic macular edema2005

    • Author(s)
      Wada M, Ogata N, Minamino S, Koriyama M, Higuchi A, Matsumura M
    • Journal Title

      Japanese Joumal of Ophthalmology 49

      Pages: 509-515

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Low levels of pigment epithelium-derived factor in highly myopic eyes with chorioreitnal atrophy2005

    • Author(s)
      Ogata N, Imaizumi M, Miyashiro M, Arichi M, Mtsuoka M, AndoA, Matsumura M
    • Journal Title

      American Jounal of Ophthalmology 140

      Pages: 937-939

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Increased levels of platelet-derived microparticles in patients with diabetic retinopathy2005

    • Author(s)
      Ogata N, Imaizumi M, Nomura S, Shouzu A, Arichi M, Matsuoka M, Matsumura M
    • Journal Title

      Diabetes Research and Clinical Practice 68

      Pages: 193-201

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Trans-Tenon's retrobulbae injection of triamcinolone acetonide for diffuse diabetic macular edema.2005

    • Author(s)
      Wada M, Ogata N, Minamino S, Koriyama M, Higuchi A, Matsumura M
    • Journal Title

      Japanese Journal of Ophthalmology 49

      Pages: 509-515

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Low levels of pigment epithelium-derived factor in highly myopic eyes with chorioretinal atrophy.2005

    • Author(s)
      Ogata N, Imaizumi M, Miyashiro M, Arichi M, Matsuoka M, Ando A, Matsumura M
    • Journal Title

      American Journal of Ophthalmology 140

      Pages: 937-939

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Increased levels of platelet-derived microparticles in patients with diabetic retinopathy.2005

    • Author(s)
      Ogata N, Imaizumi M, Nomura S, Shouzu A, Arichi M, Matsuoka M, Matsumura M
    • Journal Title

      Diabetes Research and Clinical Practice 68

      Pages: 193-201

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] In vivo evidence of angiogenesis induced by transcription factor Ets-1. Ets-1 is located upstream of angiogenesis cascade2004

    • Author(s)
      Hayashi N, Jo, N, Aoki M, Ogata N, et al.
    • Journal Title

      Circulation 109

      Pages: 3035-3041

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Deceased levels of pigment epithelium-derived factor in eyes with neuroreeetinal dystrophic diseases2004

    • Author(s)
      Ogata N, Matsuoka M, Imaizumi M, Arichi M, Matsumura M
    • Journal Title

      American Journal of Ophthalmology 137

      Pages: 1129-1130

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of pigment epithelium-derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal casculopathy2004

    • Author(s)
      Matsuoka M, Ogata N, Otsuji T, Nishimura T, Takahashi K, Matsumura M
    • Journal Title

      British Joumal of Ophthalmology 88

      Pages: 809-815

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Pigment Epithelium Derived Factor (PEDF)濃度の加齢による影響2004

    • Author(s)
      緒方奈保子, 松岡雅人, 今泉正仁, 他
    • Journal Title

      眼科臨床医報 98

      Pages: 995-997

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 糖尿病網膜症と血小板由来マイクロパーティクル2004

    • Author(s)
      緒方奈保子, 今泉正仁, 松岡雅人, 他
    • Journal Title

      臨床眼科 58

      Pages: 766-772

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] In vivo evidence of angiogenesis induced by transcription factor Ets-1. Ets-1 is located upstream of angiogenesis cascade.2004

    • Author(s)
      Hayashi N, Jo, N, Aoki M, Ogata N, et al.
    • Journal Title

      Circulation 109

      Pages: 3035-3041

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Deceased levels of pigment epithelium-derived factor in eyes with neuroretinal dystrophic diseases.2004

    • Author(s)
      Ogata N, Matsuoka M, Imaizumi M, Arichi M, Matsumura M
    • Journal Title

      American Journal of Ophthalmology 137

      Pages: 1129-1130

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of pigment epithelium-derived factor and vascular endothelial growth factor in choroidal neovascular membranes and polypoidal choroidal vasculopathy.2004

    • Author(s)
      Matsuoka M, Ogata N, Otsuji T, Nishimura T, Takahashi K, Matsumura M
    • Journal Title

      British Journal of Ophthalmol 88

      Pages: 809-815

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Pigment epithelium-derived factor in eyes an aging2004

    • Author(s)
      Ogata N, Matsuoka M, Imaizumi M, Arichi M, Matsumura M
    • Journal Title

      Japanese Review of Clinical Ophthalmology 98

      Pages: 995-997

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Platelet-derived microparticles in eyes with diabetic retinopathy.-2004

    • Author(s)
      Ogata N, Imaizumi M, Miyashiro M, Matsumura M, Shouzu A, Nomura S, Matsumura M
    • Journal Title

      Japanese journal of Clinical Ophthalmology 58

      Pages: 766-772

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Ocular angiogenesis : Disease, Mechanisms, and Therapeutics Capter 4. Polypoidal choroidal vasculopathy2006

    • Author(s)
      Ogata N, Takahashi K
    • Total Pages
      73-84
    • Publisher
      Human Press Inc.
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2007-12-13  

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