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2005 Fiscal Year Final Research Report Summary

An experimental study on resuscitation of tissue dysoxia

Research Project

Project/Area Number 16591809
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

AOKI Katsunori  Hamamatsu University School of Medicine, Professor, 医学部, 教授 (20124927)

Co-Investigator(Kenkyū-buntansha) MAGATA Yasuhiro  Hamamatsu University School of Medicine, Photon Medical Center, Professor, 光量子医学研究センター, 教授 (20209399)
YOSHINO Atsuto  Hamamatsu University School of Medicine, Associate Professor, 医学部, 助教授 (00262816)
Project Period (FY) 2004 – 2005
Keywordsdysoxia / shock / tissue oxygen metabolism / iluem / Pd-porphrin / arteriovenous shunt / endotoxin
Research Abstract

The purpose of this study was to evaluate tissue dysoxia in an experimental model of hemorrhagic shock and endotoxin shock. Ten rabbits (Japan White Rabbits, BW 3kg) were assigned to 2 groups. Group A (n=5) was resuscitated by blood transfusion and Group B (n=5) by isotonic crystalloid solution. The value of ileum serosal oxygen partial pressure was about 30 mmHg lower by the method of Pd-porphyrin phsophorescense than by the method of the oxygen electrodes. The reason why the two methods provided different data was that Pd-porphyrin phsophorescense measured the tissue oxygen pressure in the deeper layer of ileum than the oxygen electrode. The value of ileum serosal oxygen partial pressure decreased in hemorrhagic shock and showed lower than the value of venous oxygen partial pressure. This gap of oxygen partial pressure between tissue and vein was apparently seen in the group resuscitated by crystalloid solution. This shunt effect seen in the hemorrhagic shock was significantly prevented with hyperoxia. On the other hand, a decrease in ileal serosal oxygen partial pressure and persistent negative oxygen gap between tissue and vein was seen in endotoxin shock model induced by LPS(Escherichia coli-055:B5, mg/kg) in 10 animals. We conclude that tissue dysoxia may form at an early stage in hemorrhagic shock and endotoxin shock and shunting of the microcirculation may be an important contributing factor to development of multiple organ failure. To evaluate the severity of the shunting effect, new technologies aimed at the microcirculation will need to be developed about analysis of heterogenous distribution of oxygen in tissue.

  • Research Products

    (7 results)

All 2005 2004

All Journal Article (7 results)

  • [Journal Article] ショックの診断と初期治療2005

    • Author(s)
      青木克憲, 吉野篤人
    • Journal Title

      救急・集中治療 17(2)

      Pages: 271-275

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 組織酸素供給量とearly goal directed therapy2005

    • Author(s)
      青木克憲, 仁科雅良, 吉野篤人
    • Journal Title

      日本集中治療学会 12(Suppl)

      Pages: 141

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 組織酸素代謝とearly goal-directed therapy2005

    • Author(s)
      青木克憲, 吉野篤人
    • Journal Title

      日本外科代謝栄養学会 39(1)

      Pages: 5

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] MODS2005

    • Author(s)
      青木克憲
    • Journal Title

      疾患別最新処方第4版

      Pages: 32-33

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dysoxia2005

    • Author(s)
      青木克憲
    • Journal Title

      Current Therapy 23(7)

      Pages: 84-85

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] An experimental study on hypotensive resuscitation during activehemorrhage : Impact on tissue dysoxia, endo-organ function, and mortality.2004

    • Author(s)
      Aoki Katsunori et al.
    • Journal Title

      American Association for the Surgery of Trauma. Suppl.255

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A comparison of Ringer's lactate solution and Ringer's acetatesolution as resuscitation fluids in patients with extensive burns.2004

    • Author(s)
      Aoki Katsunori et al.
    • Journal Title

      Burns30 (suppl.)39

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2007-12-13  

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