2005 Fiscal Year Final Research Report Summary
Surface modification of titanium implant to control arrangement of attachment cells
| Project/Area Number |
16591951
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
ABE Yasuhiko Hiroshima University, Hospital, Assistant Professor, 病院, 講師 (00253097)
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| Co-Investigator(Kenkyū-buntansha) |
AKAGAWA Yasumasa Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究所, 教授 (00127599)
YAMANAKA Takenori Hiroshima University, Graduate School of Biomedical Sciences, Research Associate, 大学院・医歯薬学総合研究所, 助手 (20325202)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Implant / Pure titanium / Surface modification / Phospho-amino acid / Phospho-peptide / Osteoblast / Cell adhesion molecules |
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| Research Abstract |
The purpose of this study was to investigate a new biochemical surface modification technique for titanium implants using phospho-amino acids (o-phospho-L-serine, o-phospho-L-threonine) and phospho-peptides (RGDS(PO_3H_2)PA peptide, RGDXXXXXS(PO_3H_2)PA (X=MiniPEG) peptide) to control arrangement of attachment cells. X-ray photoelectron spectroscopy (XPS) and surface plasmon resonance (SPR) chemically analyzed the modified surface. It is concluded that the phospho-amino acids and the phospho-peptides chemically bonded to the titanium surface treated with HCl. These findings indicate the possibility of a new biochemical modification of titanium implant to induce specific cell and tissue responses by means of the surface immobilized with peptides, proteins, or growth factors.
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