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2005 Fiscal Year Final Research Report Summary

Development of titanium alloy for implant with high corrosion resistance and prompt bone connectivity

Research Project

Project/Area Number 16591956
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

NAKAGAWA Masaharu  Kyushu University, Dental Science, Dept. of Biomaterials, Assistant Professor, 大学院・歯学研究院, 講師 (80172279)

Co-Investigator(Kenkyū-buntansha) MATSUYA Shigeki  Kyushu University, Dental Science, Dept. of Biomaterials, Associate Professor, 大学院・歯学研究院, 助教授 (00108755)
UDOH Koichi  Yamaguchi University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (60145266)
Project Period (FY) 2004 – 2005
KeywordsTitanium / Titanium Alloy / Bioactivity / Surface Modification / Hydro-thermal Treatment / Implant / Bone Contact Ratio / Bone Connective
Research Abstract

Because titanium has an excellent corrosion resistance and a biocompatibility, it is used for an artificial hip joint and a dental implant, etc. as a metallic material for the living body. The compatibility of titanium with the bone is more excellent than that of other materials. However, there is a case removed after implantation by the micro movement etc. The aim of this research is a development of surface modification method for the titanium implant to give a strong and prompt bone.
There is a method of calling the alkali treatment to make one of the expected surface modification method extract a bone-like apatite layer directly to the surface of titanium. The material is soaked in a simulated body fluid, and the bioactivity of titanium is appreciable according to whether apatite precipitate on it.
In this study, in order to fix a small amount of Ca to the surface of titanium beforehand, a hydro-thermal treatment was given at 200C by using 10mmol/L CaCl_2 solution paying attention to the generation mechanism of apatite in vivo. Pure Ti and the Ti alloy with this treatment showed that an initial attachment and a proliferation speed of the osteoblast cell gathered from rat's bone marrow were higher than those with the alkali treatment.
The titanium implant with this treatment was implanted in rat's tibia bone and interface of bone and implant was observed. After implantation for 1 week, the bone contact rate of the titanium with this treatment indicated the more than 55% while the titanium with non-treatment indicated 5.7%. And that value reached about 100% after implantation for 4 weeks.
From the above-mentioned result, it was suggested that the hydro-thermal treatment that used the CaCl_2 solution was a surface modification method giving bioactivity for titanium.

  • Research Products

    (11 results)

All 2006 2005 2004

All Journal Article (10 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Corrosion Behavior of Pure Titanium and Titanium Alloys in Various Concentration Acidulated Phosphate Fluorides (APF) Solutions2006

    • Author(s)
      Matono Y, Nakagawa M 他
    • Journal Title

      Dental Materials Journal 25 (In press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effects of Sintering Temperature Over 1300℃ on the Physical And Compositional Properties of Porous Hydroxyapatite Foam2006

    • Author(s)
      Munar M, Udoh K, Ishikawa K, Matsuya S, Nakagawa M
    • Journal Title

      Dental Materials Journal 25 (In press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Corrosion Behavior of Pure Titanium and Titanium Alloys in Various Concentration Acidulated Phosphate Fluorides (APF) Solutions2006

    • Author(s)
      Matono, Y., Nakagawa, M.et al.
    • Journal Title

      Dental Materials Journal 25(in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of Sintering Temperature Over 1300℃ on the Physical And Compositional Properties of Porous Hydroxyapatite Foam2006

    • Author(s)
      Munar, M., Udoh, K., Ishikawa, K., Matsuya, S., Nakagawa, M.
    • Journal Title

      Dental Materials Journal 25(in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The eggect of pt and pd alloying additions on the corrosion behavior of titanium in fluoride-containing environments2005

    • Author(s)
      Nakagawa M 他
    • Journal Title

      Biomaterials 26・15

      Pages: 2239-2246

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effects of hydrothermal treatment with <CaCl_2> solution on surface property and cell response of titanium implants2005

    • Author(s)
      Nakagawa M 他
    • Journal Title

      J. Mater. Sci, Materials in Medicine 16・11

      Pages: 985-991

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Fabrivation of hydroxyapatite block from gypsum block based on <(NH_4)_2HPO_4> treatment2005

    • Author(s)
      Suzuki Y, Matsuya S, Udoh K, Nakagawa M 他
    • Journal Title

      Dental Materials Journal 24・4

      Pages: 515-521

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The effect of pt and pd alloying additions on the corrosion behavior of titanium in fluoride-containing environments2005

    • Author(s)
      Nakagawa, M. et al.
    • Journal Title

      Biomaterials 26・15

      Pages: 2239-2246

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of hydrothermal treatment with CaCl_2 solution on surface property and cell response of titanium implants2005

    • Author(s)
      Nakagawa, M. et al.
    • Journal Title

      J.Mater.Sci, Materials in Medicine 16・11

      Pages: 985-991

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Fabrication of hydroxyapatite block from gypsum block based on (NH_4)_2HPO_4 treatment2005

    • Author(s)
      Suzuki, Y., Matsuya, S., Udoh, K., Nakagawa, M.et al.
    • Journal Title

      Dental Materials Journal 24・4

      Pages: 515-521

    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] チタンまたはチタン合金の表面処理法2004

    • Inventor(s)
      中川雅晴他
    • Industrial Property Rights Holder
      中川雅晴他
    • Industrial Property Number
      特願2004-293612
    • Filing Date
      2004-10-06
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2007-12-13  

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