2005 Fiscal Year Final Research Report Summary
Intervention of GDNF to neuropathic pain
| Project/Area Number |
16592012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
SHIIBA Shunji Kyushu Dental College, Associate professor, 歯学部, 講師 (20285472)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Osamu Kyushu Dental College, Professor, 歯学部, 教授 (50137345)
SAKAMOTO Eiji Kyushu Dental College, Associate professor, 歯学部, 助手 (00295859)
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| Project Period (FY) |
2004 – 2005
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| Keywords | Neuropathic pain / GDNF / Inflammatory cytokine / CFA / Dorsal Root Ganglion / Sciatic nerve / Neuritis |
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| Research Abstract |
It was clear. that painful animal model, CFA (complete Freund's adjuvant) and CCI (chronic constriction injury) in sciatic nerve induced neuropathic pain. The pain-related behavior which these models lick hindpow and take escape behavior for heat radiation and a pin prick test. That these pain-related action is inhibited by administration of thalidomide of immunomodulator and cyclosporine S of an immunosuppressive drug, and a substance of inflammatory contributes to neuropathic pain is predicted. Therefore I paid attention to GDNF which contributed to neurotization deeply. I understood that a pain-related behavior for all algetic irritation was inhibited when I preloaded an antibody of GDNF. GDNF developed in rat dorsal root ganglia, spinal dorsal root and nerve injury region from the immediately after which nerve damage caused. I became a peak after nerve damage in three days and continued it to 14 after a disorder. This immunostaining result accords with course of rat pain-related behavioral degree. Rat sciatic nerve exposed was soaked into GDNF solution, and it developed a pain-related behavior as CFA and CFA painful model. Intervention of GDNF to neuropathic pain became clear. Early administration of an GDNF blocker after nerve injury is effective as a therapy of neuropathic pain.
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