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2006 Fiscal Year Final Research Report Summary

Methicillin-resistant staphylococci isolated from odontogenic infection

Research Project

Project/Area Number 16592023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

AKIMOTO Yoshiaki  Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (10147720)

Co-Investigator(Kenkyū-buntansha) ONO Makiko (IKEDA Makiko)  Nihon University, School of Dentistry at Matsudo, Research Assistant(Full-Time), 松戸歯学部, 助手 (00267113)
MATSUMOTO Hiroko  Nihon University, School of Dentistry at Matsudo, Lecturer(Full-Time), 松戸歯学部, 講師 (50221594)
FUJII Akira  Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (70102564)
YAMAMOTO Hirotsugu  Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (00102591)
HIRAYAMA Teruyasu  Nihon University, School of Dentistry at Matsudo, Professor, 松戸歯学部, 教授 (10189871)
Project Period (FY) 2004 – 2006
Keywordsmethicillin-resistant staphylococci / methicillin-resistant Staphylococcus aureus / methicillin-resistant Staphylococcus epidermidis / odontogenic infection / incidence of isolation / antimicrobial susceptibility / subcutanus abscess
Research Abstract

There were 611 cases of odontogenic infections in the course of the 3 years (April 2004-December 2006), in which staphylococci were isolated from 22 cases involving 16 cases of Staphylococcus aureus and 6 cases of Staphylococcus epidermidis. Concerning methicillin-resistant strain, there were one case of methicillin-resistant Staphylococcus aureus (MRSA) and two cases of methicillin-resistant Staphylococcus epidermidis (MRCoNS). The case ratios of MRSA/all odontogenic infections and MRCoNS/all odontogenic infections were 0.002 and 0.003, respectively. The frequency of both MRSA and MRCoNS were low (less than 1%). Although there were 19 cases of odontogenic infections caused by deciduous tooth infection, MRSA and MRCoNS were not isolated.
Most or all of MRSA and MRCoNS were sensitive to minocycline, arbekacin, rifampicin and vancomycin, but not sensitive to ampicillin, sulbenicillin, cefaclor, cefpiramide, flomoxef and tobramycin. Rifampicin showed the lowest MICs (< 0.1 mcg/ml). The sensitive drugs of MRSA were similar to those of MRCoNS.
In conclusion, the frequency of isolation of MRSA or MrCoNS was low. However, MRSA or MrCoNS was constantly isolated during 3 years, close attention should be paid to MRSA or MRCoNS infection in odontogenic infection.

  • Research Products

    (20 results)

All 2007 2005 2004

All Journal Article (20 results)

  • [Journal Article] Prevalence of manidipine-induced gingival overgrowth2007

    • Author(s)
      Makiko Ono 他8名
    • Journal Title

      International Journal of Oral-Medical Sciences 5・2

      Pages: 117-122

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Prevalence of manidipine-induced gingival overgrowth2007

    • Author(s)
      Makiko Ono
    • Journal Title

      International Journal of Oral-Medical Sciences 5-2

      Pages: 117-122

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 上顎洞内異物の1例2005

    • Author(s)
      西村均 他10名
    • Journal Title

      日大口腔科学 31・1

      Pages: 47-51

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Osteoma in ethmoid sinus : a case report2005

    • Author(s)
      Kazuhiro Hasegawa他12名
    • Journal Title

      International Journal of Oral-Medical Sciences 4・1

      Pages: 28-32

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cefditoren pivoxi 1経口投与後のヒト血液および口腔組織への移行2005

    • Author(s)
      小俣裕昭 他2名
    • Journal Title

      歯科薬物療法 24・2

      Pages: 64-68

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cefdinir経口投与後のヒト血液および顎骨内嚢胞への移行2005

    • Author(s)
      小俣裕昭 他2名
    • Journal Title

      日本化学療法学会雑誌 53・8

      Pages: 488-491

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] マクロライド系、ケトライド系抗歯薬を選ぶ決め手・使う術、歯性感染症2005

    • Author(s)
      小俣裕昭 他1名
    • Journal Title

      感染と抗菌薬 8・3

      Pages: 302-306

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] クラリスロマイシン経口投与後のヒト血液および口腔組織への移行2005

    • Author(s)
      小俣裕昭 他2名
    • Journal Title

      歯科薬物療法 24・3

      Pages: 103-107

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Foreign body in maxillary sinus2005

    • Author(s)
      Hitoshi Nishimura
    • Journal Title

      Nihon University Journal of Oral Science 31-1

      Pages: 47-51

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Osteoma in ethmoid sinus : a case report2005

    • Author(s)
      Kazuhiro Hasegawa
    • Journal Title

      International Journal of Oral-Medical Sciences 4-1

      Pages: 28-32

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cefditoren pivoxil concentrations in human serum and oral tissues following a single oral administration2005

    • Author(s)
      Hiroaki Omata
    • Journal Title

      Oral Therapeutics and Pharmacology 24-2

      Pages: 64-68

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cefdinir concentrations in human serum and jaw cyst after oral administration of cefdinir2005

    • Author(s)
      Hiroaki Omata
    • Journal Title

      Journal of Chemotherapy 53-8

      Pages: 488-491

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Macrolides and ketolides in the treatment of odontogenic infection2005

    • Author(s)
      Hiroaki Omata
    • Journal Title

      Infection and Antimicrobial Agents 8-3

      Pages: 302-306

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clarithromycin concentrations in human serum and oral tissues following a single oral administration2005

    • Author(s)
      Hiroaki Omata
    • Journal Title

      Oral Therapeutics and Pharmacology 24-3

      Pages: 103-107

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cefdinir経口投与後のヒト血液および口腔組織への移行2004

    • Author(s)
      小俣裕昭 他4名
    • Journal Title

      日本化学療法学会雑誌 52・5

      Pages: 265-269

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cefuroxime axetil経口投与後のヒト血液および口腔組織への移行2004

    • Author(s)
      小俣裕昭 他4名
    • Journal Title

      歯科薬物療法 23・3

      Pages: 73-78

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Levofloxacin経口投与後のヒト血液および口腔組織への移行2004

    • Author(s)
      小俣裕昭 他4名
    • Journal Title

      歯科薬物療法 23・3

      Pages: 88-92

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cefdinir concentrations in human serum and oral tissues after oral administration of cefdinir2004

    • Author(s)
      Hiroaki Omata
    • Journal Title

      Journal of Chemotherapy 52-5

      Pages: 265-269

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cefuroxime concentrations in human serum and oral tissues following a single oral administration of cefuroxime axetil2004

    • Author(s)
      Hiroaki Omata
    • Journal Title

      Oral Therapeutics and Pharmacology 23-3

      Pages: 73-78

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Levofloxacin concentrations in human serum and oral tissues following a single oral administration of levofloxacin2004

    • Author(s)
      Hiroaki Omata
    • Journal Title

      Oral Therapeutics and Pharmacology 23-3

      Pages: 88-92

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2008-05-27  

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