2006 Fiscal Year Final Research Report Summary
The relationship between pupil dilation response to noxious stimulation and defense response
| Project/Area Number |
16592026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
OKA Shunichi Nihon University, School of Dentistry, Assistant Professor, 歯学部, 講師 (20256879)
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| Co-Investigator(Kenkyū-buntansha) |
IMAMURA Yoshiki Nihon University, School of Dentistry, Professor, 歯学部, 教授 (90176503)
NAKAJIMA Ichiro Nihon University, School of Dentistry, Associate Professor, 歯学部, 助教授 (90198078)
OI Yoshiyuki Nihon University, School of Dentistry, Professor, 歯学部, 教授 (60271342)
ISHII Hiromitsu Nihon University, School of Dentistry, Professor, 理工学部, 教授 (20059306)
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| Project Period (FY) |
2004 – 2006
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| Keywords | pupil / somatosensory evoked potentials / noxious stimuli / defense response |
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| Research Abstract |
The pupil dilates markedly in response to increasing noxious stimulation in humans. However, a central unresolved issue is whether this pupil dilation response (PDR) is a spinal sympathetic reflex or not. Our previous reports indicate that the PDR could be a brain-mediated response such as a defense response, and examined two experiments as follows :
Experiment 1 : We examined whether PDR amplitude is increased by unexpected stimuli(B,C,D) compared to expected stimuli(A)
Result : The amplitude of PDR to D significantly increased compared to that to A.
Experiment 2 : We examined whether the amplitude in PDR,SEP are decreased during propofol sedation(0.3,0.6,0.9μg/ml=0.3P、0.6P、0.9P)
Result :
1. The amplitude of SEP to noxious stimulation during 0.6P,0.9P significantly decreased compared to that to control.
2. The amplitude of PDR to strong stimulation during 0.9P significantly decreased compared to that to control.
3. The VAS during 0.9P significantly decreased compared to that to control.
4. BIS value were positively related to PDR,SEP and VAS with strong stimulation.
We concluded that PDR to noxious stimulation
(1) increases the amplitude with increasing anxiety.
(2) is an objective parameter for pain.
(3) is an objective parameter for sedation level.
(4) is a more complex brain response.
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