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2005 Fiscal Year Final Research Report Summary

Pathophysiological analysis of sleep-disordered breathing using mouse model of the disease

Research Project

Project/Area Number 16614007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 睡眠学
Research InstitutionKyoto University

Principal Investigator

KADOTANI Hiroshi  Kyoto University, Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (90362516)

Project Period (FY) 2004 – 2005
KeywordsSleep / Sleep Apnea Syndrome / Sleep-disordered Breathing / Metabolic Syndrome / Brain Machine Interface
Research Abstract

Hypoxia and hypercapnia may cause arousal from sleep and sleep fragmentation in human obstructive sleep apnea syndrome. Recently, several reports presented chronic repetitive ambient hypoxia as a rodent model of sleep-disordered breathing. However, with such a model, it is not possible to elucidate the relative roles of hypercapnia as well as hypoxia on sleep and vigilance. Thus, we made a mouse model of sleep-induced hypercapnia and/or hypoxia to assess this question.
With our model, we disrupted mouse from sleep for a week. As a result, not only sleep rebound, but also hypertension and hyperglycemia were induced in the mouse. This model may be very useful to elucidate interaction between sleep-disordered breathing and metabolic syndrome.

  • Research Products

    (29 results)

All 2006 2005 2004 Other

All Journal Article (23 results) Book (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Resetting of peripheral circadian clock by prostaglandin E2.2005

    • Author(s)
      Tsuchiya, Y, Minami, I, Kadotani, H, Nishida,E.
    • Journal Title

      EMBO Report 6・3

      Pages: 256-261

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 睡眠時無呼吸症候群になりやすい体質は?2005

    • Author(s)
      角谷寛
    • Journal Title

      肥満と糖尿病 4・3

      Pages: 518-520

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ナルコレプシーとは?2005

    • Author(s)
      角谷寛
    • Journal Title

      肥満と糖尿病 4・3

      Pages: 425-427

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Resetting of peripheral circadian clock by prostaglandin E2.2005

    • Author(s)
      Tsuchiya Y, et al.
    • Journal Title

      EMBO Report 6(3)

      Pages: 256-261

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Risk factors for Sleep apnea syndrome.2005

    • Author(s)
      Kadotani H
    • Journal Title

      Obesity and Diabetes 4(3)

      Pages: 518-520

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Narcolepsy.2005

    • Author(s)
      Kadotani H
    • Journal Title

      Obesity and Diabetes 4(3)

      Pages: 425-427

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genes responsible for sleep disorders.2005

    • Author(s)
      Kadotani H
    • Journal Title

      Science journal Kagaku 75(12)

      Pages: 1421-1425

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Acceptance and short-term tolerance of nasal continuous positive airway pressure therapy in elderly patients with obstructive sleep apnea.2004

    • Author(s)
      Harada, M, Taniguchi, M, Ohi, M, Nakai, N, Okura, M, Wakamura, T, Tamura, M, Kadotani, H, Chin,K
    • Journal Title

      Sleep and Biological Rhythms 2・1

      Pages: 53-56

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Genetic approach to sleep-disordered breathing2004

    • Author(s)
      Kadotani, H, Taniguchi, M, Takahashi, Y, Inoue,Y.
    • Journal Title

      Sleep and Biological Rhythms 2・S1

      Pages: S49

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 睡眠の液性調節機構と遺伝子研究2004

    • Author(s)
      角谷寛
    • Journal Title

      呼吸と循環 52・4

      Pages: 349-353

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 光の照度不足は季節性感情障害を引き起こす.2004

    • Author(s)
      角谷寛
    • Journal Title

      月刊健 33・1

      Pages: 10-11

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 高二酸化炭素・低酸素の自動制御によるマウス睡眠障害システム2004

    • Author(s)
      角谷寛
    • Journal Title

      三共生命科学研究振興財団研究報告集 20

      Pages: 61-71

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 睡眠時無呼吸症候群マウスモデル実験系について2004

    • Author(s)
      角谷寛
    • Journal Title

      文教ニュース 1811

      Pages: 11-12

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] オレキシンと睡眠2004

    • Author(s)
      角谷寛
    • Journal Title

      カレントテラピー 22・7

      Pages: 84

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] オレキシンと睡眠2004

    • Author(s)
      角谷寛
    • Journal Title

      Clinical Neuroscience 22・1

      Pages: 45-47

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Acceptance and short-term tolerance of nasal continuous positive airway pressure therapy in elderly patients with obstructive sleep apnea.2004

    • Author(s)
      Harada M, et al.
    • Journal Title

      Sleep and Biological Rhythms 2(1)

      Pages: 53-56

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genetic approach to sleep-disordered breathing.2004

    • Author(s)
      Kadotani H, et al.
    • Journal Title

      Sleep and Biological Rhythms 2(S1)

      Pages: S49

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular ApproachとSleep-controlling Mechanisms.2004

    • Author(s)
      Kadotani H
    • Journal Title

      JCLS 52(4)

      Pages: 349-253

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Light and seasonal affective disorder.2004

    • Author(s)
      Kadotani H
    • Journal Title

      Ken 33(1)

      Pages: 10-11

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mouse model of fully automated sleep disruption.2004

    • Author(s)
      Kadotani H
    • Journal Title

      Sankyo Foundation of Life Science 20

      Pages: 61-71

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mouse model of Sleep apnea syndrome.2004

    • Author(s)
      Kadotani H
    • Journal Title

      Bunkyo News 1811

      Pages: 11-12

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Orexin and Sleep.2004

    • Author(s)
      Kadotani H
    • Journal Title

      Current Therapy 22(7)

      Pages: 84

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Orexin and Sleep.2004

    • Author(s)
      Kadotani H
    • Journal Title

      Clinical Neuroscience 22(1)

      Pages: 45-47

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 睡眠時呼吸障害の疫学と社会的インパクト 睡眠時呼吸障害Update2006.(井上雄一, 山城義広(編))2006

    • Author(s)
      角谷 寛
    • Publisher
      日本評論社(in press)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 生活習慣病における睡眠時無呼吸症候群の臨床的意義をみる睡眠障害治療の新たなストラテジー : -生活習慣病からみた不眠症治療の最前線-.(清水徹男(編))2006

    • Author(s)
      角谷 寛, 宮崎総一郎
    • Publisher
      先端医学社(in press)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Epidemiology and social impacts of Sleep apnea syndrome. (Sleep-disordered Breathing Update)2006

    • Author(s)
      Kadotani H
    • Publisher
      Nihon Hyoron Sya(in press)
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Sleep apnea syndrome and metabolic syndrome. (New strategies for sleep disorders)

    • Author(s)
      Kadotani H
    • Publisher
      Sentanigaku(in press)
    • Description
      「研究成果報告書概要(欧文)」より
  • [Patent(Industrial Property Rights)] 睡眠障害実験システム2004

    • Inventor(s)
      角谷寛, 南一成, 竹川高志
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      特願2005-154821
    • Filing Date
      2004-05-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] レストレスレッグス症候群・周期性四肢運動障害モデル動物2004

    • Inventor(s)
      角谷寛
    • Industrial Property Rights Holder
      科学技術振興機構
    • Industrial Property Number
      特願2004-162468
    • Filing Date
      2004-05-31
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2007-12-13  

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