2005 Fiscal Year Final Research Report Summary
Study on a novel mechanism by which IgE/FcεRI mediates chronic allergic inflammation
| Project/Area Number |
16616004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
アレルギー
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KARASUYAMA Hajime Tokyo Medical and Dental University, Graduate School, Professor, 大学院・医歯学総合研究科, 教授 (60195013)
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| Co-Investigator(Kenkyū-buntansha) |
MINEGISHI Yoshiyuki Tokyo Medical and Dental University, Associate Professor, 大学院・医歯学総合研究科, 助教授 (10343154)
NISHIKAWA Kiyoshi Tokyo Medical and Dental University, Emeritus Professor, 名誉教授 (20077647)
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| Project Period (FY) |
2004 – 2005
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| Keywords | chronic allergy / atopic dermatitis / model mice / IgE / T cell / mast cell / basophil / eosinophil |
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| Research Abstract |
The recruitment of basophils into the sites of allergic inflammation is often observed. However, no definitive evidence has been provided that basophils are crucially involved in the pathogenesis of chronic allergic disorders. Basophils represent less than 1% of peripheral blood leukocytes. and have often been considered as minor and possibly redundant "circulating mast cells". In this study, we have demonstrated that basophils play an important and non-redundant role and are responsible for the development of IgE-mediated chronic allergic inflammation, independently of T cells and mast cells. A single subcutaneous injection of multivalent antigens elicited not only immediate- and late-phase ear swelling but also delayed-onset ear swelling with massive eosinophil infiltration in mice sensitized with antigen-specific IgE and IgE transgenic mice. Mast cells were essential for the immediate- and late-phase ear swelling but dispensable for the delayed one. T cells were also dispensable for the latter. The delayed-onset allergic inflammation was not developed in FcεRI-deficient mice, but it was restored in these mice by transferring FcεRI-expressing basophils from normal mice. These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the-interaction of antigen, IgE, and FcεRI. The present study implies that basophils and their products could be good targets to treat this type of chronic allergic inflammation.
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[Journal Article] Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration.2005
Author(s)
Omata, N., Ohshima, Y., Yasutomi, M., Yamada, A., Karasuyama, H., Mayumi, M.
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Journal Title
The Journal of Allergy and Clinical Immunology 115
Pages: 822-827
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.2005
Author(s)
Shinohara, H., Inoue, A., Toyama-Sorimachi, N., Nagai, Y., Yasuda, T., Suzuki, H., Horai, R., Iwakura, Y., Yamamoto, T., Karasuyama, H., Miyake, K., Yamanashi, Y.
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Journal Title
The Journal of Experimental Medicine 201
Pages: 333-339
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner.2005
Author(s)
Toyama-Sorimachi, N., Omatsu, Y., Onoda, A., Tsujimura, Y., Iyoda, T., Kikuchi-Maki, A., Sorimachi, H., Dohi, T., Taki, S., Inaba, K., Karasuyama, H.
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Journal Title
The Journal of Immunology 74
Pages: 4621-4629
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Activation of NFκ-B promotes the transition of large, CD43^+ pre-B cells to small, CD43^- pre-B cells.2005
Author(s)
Jimi, E., Phillips, R.J., Rincon, M., Voll, R., Karasuyama, H., Flavell, R., Ghosh, S.
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Journal Title
International Immunology 17
Pages: 815-825
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells.2005
Author(s)
Mukai, K., Matsuoka, K., Taya, C., Suzuki, H., Yokozeki, H., Nishioka, K., Hirokawa, K., Etori, M., Yamashita, M., Kubota, T., Minegishi, Y., Yonekawa, H., Karasuyama, H.
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Journal Title
Immunity 23
Pages: 191-202
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling.2005
Author(s)
Shinohara, H, Inoue, A, Toyama-Sorimachi, N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K, Yamanashi Y.
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Journal Title
The Journal of Experimental Medicine 201
Pages: 333-339
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways.2004
Author(s)
Maezawa, Y., Nakajima, H., Seto, Y., Suto, A., Kumano, K., Kubo, S., Karasuyama, H., Saito, Y., Iwamoto, I.
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Journal Title
Clinical and Experimental Immunology 135
Pages: 12-18
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Deficiency of BLNK hampers PLC-γ2 phosphorylation and Ca2+ influx induced by the pre-B cell receptor in human pre-B cells.2004
Author(s)
Taguchi, T., Kiyokawa, N., Takenouchi, H., Matsui, J., Tang, W., Nakajima, H., Suzuki, K., Shiozawa, Y., Saito, M., Katagiri, Y.U., Takahashi, T., Karasuyama, H., Matsuo, Y., Okita, H., Fujimoto, J.
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Journal Title
Immunology 112
Pages: 575-582
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma.2004
Author(s)
Kiyokawa, N., Sekino, T., Matsui, T., Takenouchi, H., Mimori, K., Tang, W.R., Matsui, J., Taguchi, T., Katagiri, Y.U., Okita, H., Matsuo, Y., Karasuyama, H., Fujimoto, J.
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Journal Title
Modern Pathology 17
Pages: 423-429
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Ly49Q, a member of Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.2004
Author(s)
Toyama-Sorimachi, N., Tsujimura, Y., Maruya, M., Onoda, A., Kubota, T., Koyasu, S., Inaba, K., Karasuyama, H.
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Journal Title
Proceedings of the National Academy of Sciences of the USA 101
Pages: 1016-1021
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Diagnostic importance of CD 179a/b as markers of precursor B-cell lymphoblastic lymphoma.2004
Author(s)
Kiyokawa, N., Sekino, T., Matsui, T., Takenouchi, H., Mimori, K., Tang, W.R., Matsui, J., Taguchi, T., Katagiri, Y.U., Okita, H., Matsuo, Y., Karasuyama, H., Fujimoto, J.
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Journal Title
Modern Pathology 17
Pages: 423-429
Description
「研究成果報告書概要(欧文)」より
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