タンパク質の多様性獲得戦略の解明に基づいたゲノム情報の解読

2004 Fiscal Year Annual Research Report

• Project/Area Number: 16637005
• Research Institution: Nagahama Institute of Bio-Science and Technology
• Principal Investigator: 郷 通子 長浜バイオ大学, バイオサイエンス学部, 教授 (70037290)
• Co-Investigator(Kenkyū-buntansha): 高橋 健一 長浜バイオ大学, バイオサイエンス学部, 助教授 (20322737) ; 加藤 晃一 名古屋市立大学, 大学院・薬学研究科, 教授 (20211849) ; 鈴木 利治 北海道大学, 大学院・薬学研究科, 教授 (80179233) ; 古川 清 財団法人東京都高齢者研究, 福祉振興財団, 副参事研究員 (10190133) ; 由良 敬 日本原子力研究所, 計算科学技術推進センター, 副主任研究員 (50252226)
• Keywords: タンパク質の多様化 / ゲノム情報 / 選択的スプライシング / RNA編集 / 翻訳後修飾 / 選択的プロテオリシス / プロテインスプライシング / 抗体の多様性獲得

Research Abstract

生物がゲノムに内包された限られた数の遺伝子を駆使して天文学的ともいえるタンパク質の多様性を獲得している戦略の全体像を俯瞰的に捉えることは、ゲノム情報を読み解くうえで極めて重要である。そこで、以下のような企画調査を行い、タンパク質多様性獲得戦略に関するこれまでの研究と今後の展開に対する指針を検討した。
2回の班会議の開催(7月16-17日、長浜;12月4日、東京)、3回の公開シンポジウムの開催(第27回日本分子生物学会年会ワークショップW3E「タンパク質の多様性獲得戦略」、12月10日、神戸;「選択的スプライシングによる多様性の創造」、12月4日、東京;「Strategies for the acquirement of functional diversity of proteins(タンパク質の多様性は限られたゲノム情報からいかにして生み出されるか?)」、1月20日、東京)、5名の海外研究者の招聘(Adrian R.Krainer(Cold Spring Harbor Laboratory)、E.Yvonne Jones(University of Oxford)、Claudio Joazeiro(Genomics Institute of the Novartis Research Foundation)、Michiko N.Fukuda(The Burnham Institute)、Jianxin Bao(Washington University))。
これらの活動を通して得た指針に基づき、タンパク質多様性獲得戦略の全体像把握に向けた研究を推進していくために、科学研究費補助金「特定領域研究」の平成17年度新規発足申請(申請領域名「タンパク質機能の多様性獲得戦略」)を行った。

Research Products

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  • Filing Date: 2005-02-28