2017 Fiscal Year Annual Research Report
バイオマスの有効利用を指向した光と金属触媒を用いる炭素－炭素結合切断反応の開発
| Project/Area Number |
16F16340
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| Research Institution | Kyoto University |
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Principal Investigator |
村上 正浩 京都大学, 工学研究科, 教授 (20174279)
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| Co-Investigator(Kenkyū-buntansha) |
ZHOU WANG 京都大学, 工学(系)研究科(研究院), 外国人特別研究員
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| Project Period (FY) |
2016-10-07 – 2019-03-31
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| Keywords | alkene / C-C bond cleavage / photocatalysis / pyridine N-oxide / ortho-alkylation |
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| Outline of Annual Research Achievements |
Pyridines are prevalent structural units in drug molecules. Developing methods for the synthesis of alkylated pyridine have attracted an increasing interest since chemical modification of pyridine core, especially at later-stages, will offer a rapid access to the analogues of clinical candidates that is particularly important in the drug discovery process. we have developed a photo-induced alkylation reaction of pyridine N-oxides by using alkenes as alkylating reagents (ACIE, 2018, 57, 5139). This strategy was successfully applied to the reaction of a variety of N-oxides and alkenes, yielding pyridines having benzylic and secondary alkyl groups at the ortho-position.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
My research focus now shift to another topic, photo-induced synthesis of alfa-(pyridin-2-yl)styrene from selective coupling between aryl halide and 2-vinylpyridine. Everything is underway as planed.
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| Strategy for Future Research Activity |
For the following fiscal year, we will focus on photo-induced synthesis of alfa-(pyridin-2-yl)styrene from selective coupling between aryl halide and 2-vinylpyridine. The viability of our design will be first tested. If it works, we will turn to the optimal reaction conditions.
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