2017 Fiscal Year Annual Research Report

目標に向かう空間ナビゲーションのための視床下部ー海馬回路の機能解明

Research Project

Project/Area Number	16F16386
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	McHugh Thomas 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (50553731)
Co-Investigator(Kenkyū-buntansha)	CHEN SHUO 国立研究開発法人理化学研究所, 脳科学総合研究センター, 外国人特別研究員
Project Period (FY)	2016-10-07 – 2018-03-31
Keywords	hippocampus / hypothalamus / neural circuit / social memory / spatial memoy
Outline of Annual Research Achievements	Optogenetic stimulation of SuM terminals did not impair social behavior, but we found that inhibition of these projections leads to profound deficits in spatial working memory and context novelty detection. In vivo recordings during T-maze behavior combined with optogenetics revealed that the silencing of these inputs impairs trajectory specific firing rate modulation of CA1 pyramidal cells in a manner that correlates with changes in behavior. These data establish that SuM input into the DG serves as a novel modulation of hippocampal spatial memory. We are currently conducting analyses to understand how these phenotypes relate to alterations in hippocampal oscillations and dynamic information routing in the circuit.
Research Progress Status	29年度が最終年度であるため、記入しない。
Strategy for Future Research Activity	29年度が最終年度であるため、記入しない。