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2008 Fiscal Year Final Research Report

Pursuit of Substances in Dynamic Ecological Systems

Research Project

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Project/Area Number 16GS0206
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research InstitutionKeio University (2008)
Nagoya University (2004-2007)

Principal Investigator

UEMURA Daisuke  Keio University, 理工学部, 教授 (00022731)

Co-Investigator(Kenkyū-buntansha) ARIMOTO Hirokazu  東北大学, 大学院・生命科学研究科, 教授 (60262789)
YOSHIDA Kumi  名古屋大学, 大学院・情報科学研究科, 准教授 (90210690)
KITA Masaki  筑波大学, 大学院・数理物質科学研究科, 講師 (30335012)
OHNO Osamu  名古屋大学, 大学院・理学研究科, 助教 (20436992)
Project Period (FY) 2004 – 2008
Keywords生態系ダイナミズム / 物質探索 / 生物活性評価 / 抗腫瘍性 / 脂肪蓄積阻害
Research Abstract

自然界での生物現象から真摯に学び、特異な生態系でくり広げられる生物現象を「生態系ダイナミズム」という視点で着目し、現象に関与する切れ味の良い有用天然有機分子の探索を試みた。また、新規化合物の単離・構造決定のみで満足することなく、化合物の展開利用までを視野に入れた姿勢で化学合成と生物学的意義の解明を目指した研究に取り組み、複数の重要化合物の発見及びその機能解明を達成した。本研究により、サンゴ幼生誘引物質や哺乳類毒の解明等これまで未解明であった現象に関与する物質を解明するとともに、関連科学分野への波及性を発揮する新規天然有機化合物の発見を導くことができ、生物分子科学の新領域を創成した。

  • Research Products

    (29 results)

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (7 results) Book (5 results) Remarks (1 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Recent aspects of chemical ecology : Natural toxins, coral communities, and symbiotic relationships2009

    • Author(s)
      D. Uemura, M. Kita, H. Arimoto, M. Kitamura
    • Journal Title

      Pure Appl. Chem. 81(in press)

      Pages: 1093-1111

    • Peer Reviewed
  • [Journal Article] Whole Structure-Activity Relationships of the Fat-Accumulation Inhibitor (-)-ternatin : Recognition of the Importance of Each Amino Acid Residue2008

    • Author(s)
      K. Shimokawa, Y. Iwase, R. Miwa, K. Yamada, D. Uemura
    • Journal Title

      J. Med. Chem. 51

      Pages: 5912-5914

    • Peer Reviewed
  • [Journal Article] Biological activity, structural features, and synthetic studies of (-)-ternatin, a potent fat-accumulation inhibitor of 3T3-L1 adipocytes2008

    • Author(s)
      K. Shimokawa, I. Mashima, A. Asai, T. Ohno, K. Yamada, M. Kita, D. Uemura
    • Journal Title

      Chem. Asian J. 3

      Pages: 348-3446

    • Peer Reviewed
  • [Journal Article] Asymmetric Total Synthesis of Pinnaic Acid2007

    • Author(s)
      S. Xu, H. Arimoto, D. Uemura
    • Journal Title

      Angew. Chem. Int. Ed. 46

      Pages: 5746-5749

    • Peer Reviewed
  • [Journal Article] Symbiodinolide, a novel polyol macrolide that activates N-type Ca^<2+> channel, from the symbiotic marine dinoflagellate Symbiodinium sp2007

    • Author(s)
      M. Kita, N. Ohishi, K. Konishi, M. Kondo, T. Koyama, M. Kitamura, K. Yamada, D. Uemura
    • Journal Title

      Tetrahedron 63

      Pages: 6241-6251

    • Peer Reviewed
  • [Journal Article] Molecular Shape of Palytoxin in Aqueous Solution2007

    • Author(s)
      T. Inuzuka, T. Fujisawa, H. Arimoto, D. Uemura
    • Journal Title

      Org. Biomol. Chem. 5

      Pages: 897-899

    • Peer Reviewed
  • [Journal Article] Identification of Proteins from Venom of the Paralytic Spider Wasp2007

    • Author(s)
      T. Yamamoto, H. Arimoto, T. Kinumi, Y. Oba, D. Uemura
    • Journal Title

      Cyphononyx dorsalis, Insect Biochem. Mol. Biol. 37

      Pages: 278-286

    • Peer Reviewed
  • [Journal Article] Bioorganic Studies on Marine Natural Products.-Diverse Chemical Structures and Bioactivities-2006

    • Author(s)
      D. Uemura
    • Journal Title

      Chem. Rec. 6

      Pages: 235-248

    • Peer Reviewed
  • [Journal Article] Blarina toxin, a mammalian lethal venom from the short-tailed shrew Blarina brevicauda : isolation and characterization2004

    • Author(s)
      M. Kita, Y. Nakamura, Y. Okumura, S. D. Ohdachi, Y. Oba, M. Yoshikuni, H. Kido, D. Uemura
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A. 101

      Pages: 7542-7547

    • Peer Reviewed
  • [Journal Article] Symbioimine Exhibiting Inhibitory Effect of Osteoclast Differentiation, from the Symbiotic Marine Dinoflagellate Symbiodinium sp.2004

    • Author(s)
      M. Kita, M. Kondo, T. Koyama, K. Yamada, T. Matsumoto, K. H. Lee, J. T. Woo, D. Uemura
    • Journal Title

      J. Am. Chem. Soc. 126

      Pages: 4794-4795

    • Peer Reviewed
  • [Presentation] Diverse Chemical Structures and Bioactivities of Marine Natural Products2008

    • Author(s)
      D. Uemura
    • Organizer
      The 22nd NaitoConference "Chemical Biorogy I"
    • Place of Presentation
      札幌
    • Year and Date
      2008-09-10
  • [Presentation] Aspects of Chemical Ecology2008

    • Author(s)
      D. Uemura
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products ICOB-6 & ISCNP-26
    • Place of Presentation
      シャーロットタウン(カナダ)
    • Year and Date
      2008-07-18
  • [Presentation] Bioactive Metabolites from the Symbiotic Dinoflagellates2007

    • Author(s)
      D. Uemura
    • Organizer
      1st Brazilian Conference on Natural Products
    • Place of Presentation
      サンパウロ(ブラジル)
    • Year and Date
      2007-11-05
  • [Presentation] Diverse Chemical Structures and Bioactivities of Marine Natural Products2007

    • Author(s)
      D. Uemura
    • Organizer
      The VIth U.S.-JAPAN Symposium on Marine Bioorganic Chemistry
    • Place of Presentation
      ソルトレイクシティー(米国)
    • Year and Date
      2007-07-02
  • [Presentation] Allelochemicals of Crustose Coralline Red Algae for Coral Larvae2006

    • Author(s)
      D. Uemura
    • Organizer
      Gordon Coference 2006-Marine Natural Products-
    • Place of Presentation
      ベンチュラ(米国)
    • Year and Date
      2006-02-27
  • [Presentation] Bioorganic Studies of Super-carbon-chain Metabolites from Symbiotic Dinoflagellate2005

    • Author(s)
      D. Uemura
    • Organizer
      Pacifichem 2005
    • Place of Presentation
      ハワイ(米国)
    • Year and Date
      2005-12-16
  • [Presentation] Bioactive Iminium Alkaloids from Marine Invertibrates2005

    • Author(s)
      D. Uemura
    • Organizer
      20th International Congress of Heterocyclic Chemistry (ICHC2005)
    • Place of Presentation
      パレルモ(イタリア)
    • Year and Date
      2005-08-01
  • [Book] Pheromones of marine invertebrates and algae. in Comprehensive Natural Products Chemistry(Elsevier, Amsterdam)(Ed. K. Mori)(Vol.4)2009

    • Author(s)
      M. Kita, M. Kitamura, D. Uemura
    • Publisher
      2nd Edition(in press)
  • [Book] 入門ケミカルバイオロジー(入門ケミカルバイオロジー編集委員会編)2008

    • Author(s)
      上村大輔、中村和彦
    • Total Pages
      67-81
    • Publisher
      オーム社
  • [Book] 新規素材探索-医薬品リード化合物・食品素材を求めて-2008

    • Author(s)
      上村大輔監修
    • Total Pages
      313
    • Publisher
      (株)シーエムシー出版
  • [Book] 生命科学への展開、岩波講座現代化学への入門第15巻2006

    • Author(s)
      上村大輔、袖岡幹子(共著)
    • Total Pages
      246
    • Publisher
      岩波書店
  • [Book] Shellfish poisons. in Marine Molecular Biotechnolog(Eds W. E. G. Muller and H. G. Schroder)(Springer-Verlag Press, D-Berlin)2006

    • Author(s)
      M. Kita, D. Uemura
    • Total Pages
      25-51
    • Publisher
      Heidelberg
  • [Remarks]

    • URL

      http://www.bio.keio.ac.jp/labs/uemura/gakujutsu/results.html

  • [Patent(Industrial Property Rights)] ルテニウム錯体を用いる1, 2-ジオールの開裂反応2008

    • Inventor(s)
      上村大輔、韓春光
    • Industrial Property Rights Holder
      上村大輔
    • Industrial Property Number
      特許, 特願2008-219516
    • Filing Date
      2008-08-28
  • [Patent(Industrial Property Rights)] アントシアニジン類の製造方法及びフラベノール誘導体2007

    • Inventor(s)
      吉田久美、近藤忠雄、尾山公一
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      特許, 特願2007-317648
    • Filing Date
      2007-12-07
  • [Patent(Industrial Property Rights)] 環状ヘプタペプチド及びその用途2007

    • Inventor(s)
      上村大輔、下川賢一郎、岩瀬賢明、山田薫
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Number
      特許, 特願2007-220131、PCT/JP 2008/060486
    • Filing Date
      2007-08-27
  • [Patent(Industrial Property Rights)] スピロ[1-アザビシクロ[4.4.0]デカ-3エン-9,1'-シクロペンタン]誘導体2006

    • Inventor(s)
      上村大輔、倉本誠、周丹、山田薫
    • Industrial Property Rights Holder
      上村大輔
    • Industrial Property Number
      特許, 特願平08-022200、特開平09-208588、特許第3879088号登録
    • Filing Date
      2006-11-17
  • [Patent(Industrial Property Rights)] 新規安息香酸ベンジル誘導体及び医薬2005

    • Inventor(s)
      上村大輔、北将樹、松本漠、諏佐智之、山田薫、矢澤一良、山口宏二、叶茂
    • Industrial Property Rights Holder
      名古屋大学、東京海洋大学
    • Industrial Property Number
      特許, 特願2005-366790、特開2007-169188
    • Filing Date
      2005-12-20
  • [Patent(Industrial Property Rights)] 脂肪細胞の脂肪蓄積阻害剤2005

    • Inventor(s)
      上村大輔、北将樹、大野美季、山田薫、大野智弘
    • Industrial Property Rights Holder
      株式会社ファンケル
    • Industrial Property Number
      特許, 特願 2005-028203、特開2006-213648
    • Filing Date
      2005-02-03

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Published: 2010-06-10   Modified: 2016-04-21  

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