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2018 Fiscal Year Annual Research Report

Molecular mechanisms for IgA-mediated regulations of host-microbiota symbiosis

Research Project

Project/Area Number 16H02632
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

ファガラサン シドニア  国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (00391970)

Co-Investigator(Kenkyū-buntansha) 服部 正平  早稲田大学, 理工学術院, 教授(任期付) (70175537)
Project Period (FY) 2016-04-01 – 2019-03-31
KeywordsImmunology / IgA
Outline of Annual Research Achievements

We previously demonstrated that gut IgAs contribute to regulating the gut bacterial communities, but the mechanisms involved in such regulation remained unknown. We speculated that not only the repertoire but also the post-translational modifications might be different between IgAs elicited in different conditions (for example non-selected or “default” IgA versus adaptive, selected or “homeostatic” IgA). Thus we analyzed the properties of IgA from genetically modified mice lacking germinal centers, such as T cell deficient mice, or germ-free (GF) mice as well as gnotobiotic mice. We found that the “default” IgAs were heavily glycosylated and that the addition of bacteria drastically modified the sugar contents of IgAs. Sequencing analyses of bacteria coated with different IgA qualities will be analyzed in collaboration with the group of Professor Hattori. Furthermore, different bacterial species generated different glycosylation profiles, implicating that not only the immune system but also the microbiota contribute to biochemical characteristics of IgA in the gut. We began to dissect the importance of such post-translational modifications of IgA in the contexts of symbiotic interactions. The studies will be continued in the coming years. We believe that such fundamental research will contribute to deeper understanding of the basic principles governing the homeostasis at the mucosal surface. It will also allow envisioning strategies aiming to restore homeostasis in diseases accompanied by changes in microbiota composition and function.

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

  • Research Products

    (2 results)

All 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria2018

    • Author(s)
      Nakajima Akira、Vogelzang Alexis、Maruya Mikako、Miyajima Michio、Murata Megumi、Son Aoi、Kuwahara Tomomi、Tsuruyama Tatsuaki、Yamada Satoshi、Matsuura Minoru、Nakase Hiroshi、Peterson Daniel A.、Fagarasan Sidonia、Suzuki Keiichiro
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 215 Pages: 2019~2034

    • DOI

      10.1084/jem.20180427

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 1.Involvement of T cells in antibody diversification and shaping of the microbial landscape.2018

    • Author(s)
      Sidonia Fagarasan
    • Organizer
      The Franco-Japanese seminar on Immunology
    • Int'l Joint Research / Invited

URL: 

Published: 2019-12-27  

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