2019 Fiscal Year Final Research Report
Development of Ultrasound Lithotripsy with High Throughput and Accuracy using Acoustic Cavitation
| Project/Area Number |
16H03160
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
梅村 晋一郎 東北大学, 医工学研究科, 学術研究員 (20402787)
|
|---|
| Project Period (FY) |
2016-04-01 – 2020-03-31
|
| Keywords | キャビテーション / 結石破砕 / 集束超音波 |
|---|
| Outline of Final Research Achievements |
A HIFU transducer which has two resonance frequencies was developed. Cavitation bubbles were generated by the newly developed transducer or existing transducers and observed by high-speed photography and ultrasound imaging to investigate the behavior of the cavitation bubbles. A HIFU exposure method was proposed to erode a renal stone using cavitation bubbles efficiently. The result in the experiment of the erosion of model stones in a water tank showed the efficiency of the proposed method.
|
| Free Research Field |
医用超音波
|
| Academic Significance and Societal Importance of the Research Achievements |
HIFU照射によって発生するキャビテーション気泡は，結石破砕のみならず，HIFUによるがんなどの治療や，HIFUを用いたドラッグデリバリーなどの分野でも利用が期待されている．したがって，本研究で得られたキャビテーション気泡の挙動に関する知見は，それらの分野への展開も期待できる．また，近年はレーザ技術等の進歩により経尿道的尿路結石除去術 （TUL）が発展してきているが，体外式のHIFUを用いた高効率かつ安全な結石破砕法は，より低侵襲で高速な結石破砕を実現できる可能性がある．
|
