2018 Fiscal Year Final Research Report
Role of microRNAs in exercise-induced angiogenesis
| Project/Area Number |
16H03239
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 骨格筋 / メカニカルストレス / 可塑性 / 血管新生 / マイオカイン / 適応 |
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| Outline of Final Research Achievements |
In this study, we determined exercise-induced angiogenesis in mice lacking almost all miRNAs by deleting Dicer, an enzyme essential for microRNA (miRNA) processing and in mice lacking specific miRNAs.
First, the tamoxifen-induced Dicer knockout mice died within 5 weeks after tamoxifen administration, suggesting that miRNAs play an important role in maintaining life.
With regard to analysis using specific miRNA-deficient mice, even in the mice lacking miR-23 cluster miRNAs showed normal exercise-induced angiogenesis in response to endurance exercise training. These findings suggest that the role of miR-23 cluster miRNAs in exercise-induced angiogenesis in skeletal muscle is limited.
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| Free Research Field |
筋生物学，メカノバイオロジー
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によってマイクロRNAが生命維持に必須であることが示唆された．このため，マイクロRNAの機能を解析することは学術的にも社会的にも意義があると考えられる．
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