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2018 Fiscal Year Final Research Report

Development of Stimuli-Responsive Nanoscale Molecular Systems Mimicking Biological Systems

Research Project

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Project/Area Number 16H04129
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional solid state chemistry
Research InstitutionTokyo Institute of Technology

Principal Investigator

Kinbara Kazushi  東京工業大学, 生命理工学院, 教授 (30282578)

Project Period (FY) 2016-04-01 – 2019-03-31
Keywords二分子膜 / イオンチャネル / 分子機械 / 相転移 / ヒステリシス / メカノセンシティブチャネル
Outline of Final Research Achievements

Inspired by the structure of a protein contained in a cell membrane, functional amphiphilic molecules having a backbone with alternately connected hydrophilic and hydrophobic parts are designed, and their synthetic routes have been established. The designed molecules showed unique response to external thermal or physical stimuli to change its assembling structures, and resulted in the changes of their physical properties.

Free Research Field

有機化学,超分子化学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は,細胞内でタンパク質により行われている様々なセンシング,例えば温度センシングや力学センシングを,人工分子でも実現できることを示した先駆的な結果であり,ナノメートルサイズの微小センサーを構築する分子設計を可能とする,大きなブレークスルーをもたらすことが期待される。

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Published: 2020-03-30  

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