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2018 Fiscal Year Annual Research Report

Electrical TFT platform for fundamental understanding of neuromuscular communication in the aim of neuroprosthesis.

Research Project

Project/Area Number 16H04344
Research InstitutionThe University of Tokyo

Principal Investigator

ティクシェ三田 アニエス  東京大学, 先端科学技術研究センター, 准教授 (00334368)

Co-Investigator(Kenkyū-buntansha) 池内 与志穂  東京大学, 生産技術研究所, 准教授 (30740097)
年吉 洋  東京大学, 先端科学技術研究センター, 教授 (50282603)
Project Period (FY) 2016-04-01 – 2019-03-31
KeywordsBio-sensor / Integrated Device / Thin-Film-Transistor / Bio-Neural Network / Neuroprosthesis
Outline of Annual Research Achievements

During FY[2018], the platform was further improved:
1- Devices with an improved design were used; 2- A small warm chamber was designed to keep the neurons on the paltform at 37C during experiments; 3- As neurons activity is weak, improvement of the signal to noise ratio with new types of connections and set-up was performed; 4- Various improvement of the neurons culture was performed to avoid dying or inactivation of the cells.
Countrary to what was announced, muscle cells were not available in our partner laboratory. However, cortical neurons were cultured and grown as organoids (like micro-brain), and activity could be measured successfully in 2D. A new research project to study organoids communication will be proposed. In parallel, cardiomyocyte cells were cultured on the device and their activity in 2D was successfully measured. Here too, a new project is in elaboration, in which the motor neuron / cardiomyocyte system will be studied. Finally, integration of the platform with a biomimetic stimulation system was performed, and will be presented in ISMM'2019.
As a conclusion, we can say that thanks to that Kakenhi Kiban B grant, a platform for electrogenic cells activity 2D measurement and study, combined to a SNN system for biomimetic stimulation, has been developed, and will be used for new projects in the area of biomedical applications.

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

  • Research Products

    (6 results)

All 2018

All Presentation (6 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results)

  • [Presentation] Algorithmic Open-Surface Identification and Location of Droplets on a Transparent TFT Substrate for Droplet-based Microfluidics2018

    • Author(s)
      Grant Alexander Cathcart, Agnes Tixier-Mita, Satoshi Ihida, Faruk Azam Shaik, Hiroshi Toshiyoshi
    • Organizer
      The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (MICROTAS’2018)
    • Int'l Joint Research
  • [Presentation] Thin-Film-Transistor Technology: A Display Technology for Biological Applications2018

    • Author(s)
      Agnes Tixier-Mita
    • Organizer
      VDEC D2T Symposium
    • Invited
  • [Presentation] Bio-sensors Array Devices using Thin-Film-Transistor Technology2018

    • Author(s)
      Agnes Tixier-Mita
    • Organizer
      International workshop on new micro technology and translational approaches for organ regeneration and cancer therapies
    • Invited
  • [Presentation] Bio-hybrid Experiments Using Tunable Real-time Biomimetic Neural Network2018

    • Author(s)
      Farad Khoyratee,Thomas Benneteau, Agnes Tixier-Mita, Sylvain Saighi, Timothee Levi
    • Organizer
      in Proc. the 10th International Symposium on Microchemistry and Microsystems (ISMM'2018)
    • Int'l Joint Research
  • [Presentation] Thin-Film-Transistor Technology used for Biological Applications2018

    • Author(s)
      Agnes Tixier-Mita
    • Organizer
      16th NAMIS Workshop on "Micro- and nanosystems, large area electronics and biofunctionalities towards novel integrated smart systems
    • Invited
  • [Presentation] Impedance Sensing with Thin-Film-Transistors (TFT) Array Biosensors2018

    • Author(s)
      Agnes Tixier-Mita, Grant Alexander Cathcart, Faruk Azam Shaik, Satoshi Ihida, Yoshiro Ikeuchi and Hiroshi Toshiyoshi
    • Organizer
      4th Conference on Impedance-Based Cellular Assays (IBCA'2018)
    • Int'l Joint Research / Invited

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Published: 2019-12-27  

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