Development of growth factor-free tissue adhesives with angiogenic and tissue adhesive properties

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H04524
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Structural/Functional materials
• Research Institution: National Institute for Materials Science
• Principal Investigator: Taguchi Tetsushi 国立研究開発法人物質・材料研究機構, 機能性材料研究拠点, グループリーダー (70354264)
• Research Collaborator: Nishiguchi Akihiro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 接着剤

Outline of Final Research Achievements

An adhesive composed of hydrophobically-modified Alaska pollock-derived gelatin (hm-ApGltn) and a poly(ethylene glycol)-based crosslinker was obtained by introducing a hydrophobic group into original ApGltn (Org-ApGltn) having room temperature fluidity in order to create an adhesive having both angiogenic and tissue adhesive property. From the pressure test on porcine aorta, the prepared adhesive increased its pressure (adhesion) strength significantly by the introduction of hydrophobic groups. In addition, hm-ApGltn induced significantly higher production of vascular endothelial cell growth factor in macrophage-like cells as compared with Org-ApGltn. Furthermore, hm-ApGltn gel promoted angiogenesis significantly in the early stage of mouse subcutaneous implantation.

Free Research Field

医用材料、生体接着科学

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた材料は、生体内の湿潤環境において接着すると同時に、成長因子を追加することなく血管新生を誘導できることから、虚血性部位への適用や血管床を必要とする再生医療分野への展開が期待される。