2019 Fiscal Year Final Research Report
Biological role of CD280 in cancer metastasis-initiating cell
| Project/Area Number |
16H04697
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 癌転移 / スキルス胃癌 / 腹膜転移 / 分子標的 / 癌治療 |
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| Outline of Final Research Achievements |
The concept of metastasis-initiating cells (MICs) has been proposed. MICs originate in the primary tumors and are considered special cells to promote cancer metastasis. However, MICs have not been investigated in detail. We successfully isolated MICs from primary cancer tissues of a scirrhous gastric cancer patient, and then knocked out CD280 expression via genome editing methods. The CD280-deficient MICs showed the decreased proliferation, colony formation, and invasion activity compared with CD280 wild-type MICs. CD280 is a novel target to inhibit cancer metastasis.
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| Free Research Field |
腫瘍生物学
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| Academic Significance and Societal Importance of the Research Achievements |
癌転移研究は大変遅れている。その理由に、癌転移の良いモデルがない現状がある。我々は、癌転移でメインプレーヤーとなる癌転移開始細胞（MIC）を、スキルス胃癌患者から成功裡に単離した。その解析から、CD280がMICの機能維持に重要で、癌転移抑制に有用な新規標的であることが分かった。癌の死因の大半は癌転移による。故に癌患者の予後において、癌転移抑止医療が大切になる。本成果は、癌転移抑止医療の実現に繋がる社会的意義を有する。
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