2017 Fiscal Year Final Research Report
Molecular mechanism of alternative splicing regulation by phytochrome
| Project/Area Number |
16H04808
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | フィトクロム / 植物 / 光受容体 / 光応答 / 光シグナル伝達 |
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| Outline of Final Research Achievements |
Biological complexity relies on the diversity of the proteome, which can be increased beyond the number of genes. With alternative transcription start site (TSS), mRNAs are transcribed from different TSSs within a gene locus. Alternative TSS selection, evident in various organs, tissues, and cancer cells, can affect translational efficiency or stability of mRNA or alter the N-terminal lengths of the encoded proteins. However, the impact of this mechanism on the proteome and whether it is ubiquitously involved in normal organismal responses remain unclear. In this study, we show that the plant photoreceptor phytochrome induces genome-wide changes in alternative TSS selection in Arabidopsis thaliana. Through this mechanism, protein isoforms with different N-termini are produced that display light-dependent differences in localization.
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| Free Research Field |
植物光生理学
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