2019 Fiscal Year Final Research Report
Elucidation of the new pathogenic mechanism of staphylococcal superantigen toxin and its application in the next generation vaccine
| Project/Area Number |
16H05030
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Keywords | ブドウ球菌 / スーパー抗原 / 病原機構 / ワクチン |
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| Outline of Final Research Achievements |
In this study, we analyzed the adhesion and binding between Staphylococcus aureus and host cells, the receptor and its molecular signal transduction mechanism at the molecular and cellular levels, using mutant toxins and strains lacking the superantigen activity. In addition, we elucidated the mechanism of persistent infectivity of S. aureus, and the protective effect of the mutant toxin immunization at the organism level. Furthermore, the protective antigen for next-generation vaccine against staphylococcal infection have be searched, suggesting that it could be applied to a new preventive method against S. aureus infection.
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| Free Research Field |
獣医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は，ブドウ球菌と宿主細胞との付着・結合性，レセプターと分子シグナル伝達機序を解明し，生体での持続感染性および毒素免疫による感染防御機序を解析した．また，ブドウ球菌感染に対する次世代ワクチン開発に応用可能な抗原を検索した．本研究で得られる知見は動物のブドウ球菌感染症のみならず，人のHA-MRSAやCA-MRSAの感染制御にも貢献するものであると考えられる．
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