A novel immunomodulatory role of a lysophospholipid mediator, lysophosphatidylserine,, in lynphocytes.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H05085
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: AOKI JUNKEN 東北大学, 薬学研究科, 教授 (20250219)
• Research Collaborator: Ohwada Tomohiko , 教授 ; Yatomi Yutaka , 教授
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: リゾリン脂質 / 生理活性脂質 / GPCR / 抗原免疫 / B細胞

Outline of Final Research Achievements

In this study, we examined the phenotypic analyses of KO mice of LysoPS receptors which was identified in our laboratory.Since LysoPS receptors are specifically expressed in immune cells such as T and B cells, we examined the antigen immune responses in the LysoPS receptor KO mice. In the antigen-immunized model, significant increase in the numbers of T cells and B cells was observed in KO mice, which revealed that LysoPS signal exerts an immunosuppressive function. In addition, we found that LysoPS was significantly increased in the situation where lymphocytes were activated. The information will help to understand the synthetic pathway of LysoPS in the future study.

Free Research Field

生理活性脂質

Academic Significance and Societal Importance of the Research Achievements

GPCRは創薬の標的として有望である。本研究では、これまで未解明だった生理活性脂質リゾホスファチジルセリン（LysoPS）のGPCRを介する機能を世界に先駆けて明らかにすることができた。ホスファチジルセリン（PS）が免疫系に深く関与することは示唆されていたが、PSの一部はLysoPSに変換され機能することが想定される。本知見は、新規生理活性脂質の生体内機能を明らかにしたという、基礎的な貢献だけでなく、新規免疫抑制剤開発のための新たな分子標的を提供したという点においても、新規創薬を促進する極めて有用な情報となり得る。