Expanded chemical properties of novel caged NOs and biological applications

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H05103
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Nagoya City University
• Principal Investigator: Nakagawa Hidehiko 名古屋市立大学, 大学院薬学研究科, 教授 (80281674)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: ケミカルバイオロジー / 光化学 / ケージド化合物

Outline of Final Research Achievements

Nitric oxide (NO) is an essential signal mediator, but it is unstable and not easy to handle. Caged compound is one of the useful compound category, and we have been developed caged NOs and the caged compounds of the species related to NO. In this project, we have developed novel caged NOs. One of them is a caged NO responding to yellowish-green light irradiation, which was found to be applicable to ex vivo experiments. The second is a nanoparticle version of caged NO. The third one is a version of caged NO responding to red light which was also applicable to ex vivo experiments.

Free Research Field

創薬化学、ケミカルバイオロジー

Academic Significance and Societal Importance of the Research Achievements

本研究では種々のケージドNOの開発に成功し、実際に生物実験系で応用可能であることを示した。これらの化合物をさらに精査することで、NOの生理作用（血管拡張やがん細胞抑制）を利用した治療研究への応用が期待される。