2018 Fiscal Year Final Research Report
Elucidation of regulatory mechanism of diseases mediated by small GTP ase Ral
| Project/Area Number |
16H05148
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
Ogawa Osamu 京都大学, 大学院医学研究科泌尿器科, 教授
Nakase Hiroshi 京都大学, 大学院医学研究科消化器内科講師, 講師
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | がん / 代謝 / 低分子量GTP結合蛋白質 / Ral |
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| Outline of Final Research Achievements |
An inhibitor os small GTPase Ral has been developed and shown to inhibit cancer growth (Nature, 2014). Thus, the control of Ral activity is strongly noted as a drug target. We have first identified the inhibitory regulator of Ral activity, RalGAP (JBC, 2009) and reported the important role in the progression of bladder cancer (Oncogene, 2013). In the research, we have reported that the low expression of RalGAP was associated with prostate cancer progression (Carcinogenesis, in press, 2019). Further, we have found the association between RalGAP low expression and oral squamous cell carcinoma progression and also epigenetic change of RalGAP gene (in revision).
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| Free Research Field |
生化学、血栓止血学、循環器内科学
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| Academic Significance and Societal Importance of the Research Achievements |
Ral阻害薬が抗がん剤としてのポテンシャルが示された。我々の研究成果は、前立腺癌や口腔内癌でもRalの活性化が、腫瘍悪性化に関与していることを示すものであり、Ral阻害薬開発の有用性をサポートする基礎データとなる。一方、Ralの活性化は血糖降下に寄与するという知見を得つつあり、Ralの活性制御については、代謝の面からの解析も必要と考えられる。Ralに関する基礎データを提供し、創薬等に貢献していきたいと考えている。
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