2016 Fiscal Year Annual Research Report
Molecular mechanisms of bone-specific immunopathology during malaria
| Project/Area Number |
16H05181
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| Research Institution | Osaka University |
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Principal Investigator |
Coban Cevayir 大阪大学, 免疫学フロンティア研究センター, 教授 (00397712)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Bone homeostasis / Malaria / Chronic infection |
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| Outline of Annual Research Achievements |
As we proposed, in order to address how malaria infection effects bone tissue, we have set up in vivo and in vitro studies by using various mouse malaria models. For the comprehensive analysis of bone tissue, we have used microCT for bone analyses. We have set up in vitro cell cultures which enable bone marrow hematopoietic stem cells to differentiate into osteoclast and calvarial osteoblast generation during malaria infection. Our aim has been to evaluate whether the formation of osteoclast and osteoblast is impaired during malaria infection or not.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
Our initial plan to set up experimental conditions have progressed more than we expected. Therefore, our hypothesis on the effect of malaria on bone have been smoothly moving forward.
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| Strategy for Future Research Activity |
In the second year of the project, in addition to acute effect of malaria infection on bone, we will elucidate the underlying mechanism of chronic effects of malaria on bone. Furthermore, we aim to elucidate signaling molecules in bone homeostasis affected during malaria infection. We will address signaling molecules important for bone remodeling such as in osteoclasts and/or osteoblasts.
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