2017 Fiscal Year Annual Research Report
Molecular mechanisms of bone-specific immunopathology during malaria
| Project/Area Number |
16H05181
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| Research Institution | Osaka University |
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Principal Investigator |
Coban Cevayir 大阪大学, 免疫学フロンティア研究センター, 教授 (00397712)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Malaria / Bone loss / osteoporosis / Vitamin D / MyD88 / Hemozoin |
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| Outline of Annual Research Achievements |
Incomplete recovery from malaria infection causes chronic illness, and little is known of the potential outcomes of this chronicity. As we proposed bone health might be affected from chronicity of malaria infection. To address how malaria infection effects bone tissue, we set up in vivo and in vitro studies by using various mouse malaria models. We found that malaria causes bone loss and growth retardation as a result of chronic bone inflammation induced by Plasmodium products. Acute malaria infection severely suppresses bone homeostasis, but sustained accumulation of Plasmodium products in the bone marrow niche induces MyD88 dependent inflammatory responses in osteoclast and osteoblast precursors.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We have smoothly set up the experimental conditions in mice models and progressed more than we expected.
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| Strategy for Future Research Activity |
We have finalized the investigation of acute as well as chronic effects of malaria infection on bone. In the third year of the project, we will address signaling molecules important for bone remodeling such as in osteoclasts and/or osteoblasts. We will search possible signal effecting RANK-RANKL and MyD88 interaction.
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| Remarks |
http://malimm.ifrec.osaka-u.ac.jp/index.html
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Research Products
(9 results)
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[Journal Article] A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers.2017
Author(s)
Wing JB, Kitagawa Y, Locci M, Hume H, Tay C, Morita T, Kidani Y, Matsuda K, Inoue T, Kurosaki T, Crotty S, Coban C, Ohkura N, Sakaguchi S.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114
Pages: 6400
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Plasmodium products persist in the bone marrow and promote chronic bone loss2017
Author(s)
Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itagaki S, Horii T, Lin JW, Khan SM, Kuroda E, Akira S, Ishii KJ, Coban C.
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Journal Title
Science Immunology
Volume: 2
Pages: 2
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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