2018 Fiscal Year Annual Research Report
Molecular mechanisms of bone-specific immunopathology during malaria
| Project/Area Number |
16H05181
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| Research Institution | Osaka University |
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Principal Investigator |
Coban Cevayir 大阪大学, 免疫学フロンティア研究センター, 教授 (00397712)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Malaria / bone loss / Vitamin D / MyD88 / osteoblast / osteoclast / plasmodium products / tissue specificity |
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| Outline of Annual Research Achievements |
Malaria has deadly complications; however, chronic complications caused by malaria are largely neglected. Our study targeting bone during malaria infection has suggested that malaria infection causes bone loss which involves several inflammatory pathways involving osteoblasts, osteoclasts and MyD88 in response to Plasmodium products. In FY2018, we focused on the contribution of specific cells to MyD88-dependent bone loss. We generated cell type specific MyD88 deficient mice. We have made additional progress on the underlying mechanisms of malaria-induced bone loss.In our recent report, we also evaluated the possibility that the continuous malaria co-infection with EBV reactivation may also influence T cell maturation and differentiation for an increased risk of cancer.
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| Research Progress Status |
平成30年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
平成30年度が最終年度であるため、記入しない。
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