Examinational significance and production mechanism of a circulating soluble receptor for the diagnosis of activated adipocytes to prevent diabetes

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H05231
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Toho University
• Principal Investigator: BUJO Hideaki 東邦大学, 医学部, 教授 (80291300)
• Research Collaborator: HIRUTA nobuyuki ; JIANG meizi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 糖尿病 / LR11 / ブラウニング

Outline of Final Research Achievements

The study results showed that (1) the expression of browning-inhibitor gene LR11 was induced before differentiation to mature adipocytes, suggesting the induction to white adipocytes through its specific inhibition for browning, (2) beige adipocytes existed in the human body, which show the different sensitivity from other fat against the reduction therapy, and (3) among patients with diabetes and/or obesity, the changes in circulating soluble LR11 levels were not associated with those in body weights, but clearly with the degrees of accompanied diseases. These cell-biological and laboratory research results revealed that circulating sLR11 reflects pathological alteration in adipocytes, and that sLR11 is potentially a novel marker for “activated adipocytes”.

Free Research Field

臨床検査医学

Academic Significance and Societal Importance of the Research Achievements

学術的な特色は、古典的な生理学、代謝学の研究課題である褐色脂肪細胞の生成と白色脂肪のブラウニングという研究課題を平滑筋細胞のフェノタイプ変換で発見した遺伝子をもちいて明らかにしたことである。社会的意義は、多施設検査研究で得られた可溶性レセプターLR11から診断する活性化脂肪細胞にかかわる解析結果をもとに、糖尿病や肥満症の診療で、可溶性LR11という新規の診療補助検査『活性化脂肪細胞』の有用性を提示したことである。