2018 Fiscal Year Final Research Report
A randomized-control trial assessing the impact of HPV self-sampling on cervical screening uptake rates in women 20-29yrs: A comparative evaluation of two novel cervico-vaginal self-sampling devices
| Project/Area Number |
16H05253
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Hokkaido University |
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Principal Investigator |
Hanley Sharon 北海道大学, 医学研究院, 特任講師 (80529412)
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| Co-Investigator(Kenkyū-buntansha) |
松岡 悦子 奈良女子大学, 生活環境科学系, 教授 (10183948)
櫻木 範明 北海道大学, 医学研究院, 名誉教授 (70153963)
伊藤 善也 日本赤十字北海道看護大学, 看護学部, 教授 (70241437)
玉腰 暁子 北海道大学, 医学研究院, 教授 (90236737)
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| Research Collaborator |
Kakiyama Koichiro
Kate Simms
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 子宮頸がん / HPV検査 / 検診 / 自己採取 / 受診率向上 / 若年女性 |
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| Outline of Final Research Achievements |
Cervical screening has been shown to reduce incidence and mortality from cervical cancer. However, high uptake is important. Therefore, the WHO recommends uptake of 80%. Many countries are now moving from a cytology to an HPV-based screening program. Reasons for this are higher sensitivity which provides women with greater reassurance of being at very low risk of cancer if they test HPV negative, as well as reducing harm from over-screening. HPV testing also has higher sensitivity on self-collected samples helping reach under/never screened women. In this study we found that unlike in many high income countries with screening programs, In Japan, the biggest factor influencing reductions in national mortality rates was not changing from a cytology to an HPV-based screening program, but increasing screening uptake to levels recommended by the WHO. However, unlike cytology based screening programs HPV testing allows for a self-sampling to be taken, which could help increase uptake.
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| Free Research Field |
がんの疫学、公衆衛生学
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| Academic Significance and Societal Importance of the Research Achievements |
英国やオーストラリアのような先進国とは異なり、日本における子宮頸がんによる死亡者数を減少させる最も重要な要因は、どの検診法が用いられるかではなく受診率の向上であることを本研究で示すことができた点は意義深い。HPV検査は多くの国で検診受診率の向上が示されており、細胞診とは異なって自己採取検査が可能である。したがって、子宮頸がん検診ガイドラインが見直されるときには、HPV検査を正式に推奨べきであると考えられる。
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