Metabolite profiling of low-level exposure to insecticides: a milestone in the course of introduction of exposome measuring

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H05259
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Nagoya City University
• Principal Investigator: Kamijima Michihiro 名古屋市立大学, 大学院医学研究科, 教授 (80281070)
• Co-Investigator(Kenkyū-buntansha): 上山 純 名古屋大学, 医学系研究科(保健), 准教授 (00397465)
• Research Collaborator: ITO Yuki ; NAKAYAMA Shoji ; SHIBATA Eiji ; SATO Hirotaka ; OYA Naoko ; MIYAKE Mio ; MINATO Kyoko
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 殺虫剤 / 曝露評価 / リスク評価 / 尿中代謝物

Outline of Final Research Achievements

Insecticides used in the environment have been changed in the course of technical innovation. One of the risk assessment components of low-level exposure to insecticides is biological monitoring (or biomonitoring) in the exposed individuals. This research project determined the change in the insecticide use in an occupationally exposed population, analytical methods of urinary exposure markers of insecticides, intra-individual variations of metabolite concentrations of organophosphoate insecticides, and the relationship between the urinary concentrations and the esterase activity inhibition. It is expected that these results contribute to the risk assessment of insecticide exposure in the individuals.

Free Research Field

衛生学、公衆衛生学、労働衛生学、環境毒性学

Academic Significance and Societal Importance of the Research Achievements

個人の化学物質の体内負荷量を客観的に知る方法のひとつに、その物質由来の特定の物質等を生体試料中で測定する生物学的モニタリング（またはバイオモニタリング）と呼ばれる手法があるが、新規化学物質を含め、さまざまな物質への曝露を網羅的に評価することが望まれている。体内摂取後、尿中に排泄される時間が半日程度と短い殺虫剤は、新しく導入される薬剤の測定法開発とともに、１回の採尿により日々変動する排泄量の評価が正確にできるかも課題となっている。本研究ではこれらの課題に取り組み、殺虫剤のリスク評価や衛生基準設定に資する成果を得た。