2018 Fiscal Year Final Research Report
Elucidation of organ crosstalk in cardiovascular disease
| Project/Area Number |
16H05295
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Chiba University |
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Principal Investigator |
Manabe Ichiro 千葉大学, 大学院医学研究院, 教授 (70359628)
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| Co-Investigator(Kenkyū-buntansha) |
藤生 克仁 東京大学, 医学部附属病院, 特任准教授 (30422306)
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| Research Collaborator |
MATSUMOTO sahohime
HASUMI eriko
KOJIMA toshiya
NAKAYAMA yukiteru
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 心不全 / マクロファージ / 臓器連関 / 自律神経 / 心腎連関 |
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| Outline of Final Research Achievements |
Heart failure pandemic has become an important medical and social burden world-wide. We previously showed that chronic inflammation initiated in obese visceral adipose tissue activates inflammation in distant tissues, such as the pancreas and heart, and promotes cardiovascular and metabolic disease. In this study we analyzed the mechanism that link the heart and kidneys in cardiorenal syndrome. We found that the heart-brain-kidney organ networks is crucial for proper response to cardiac stress. Dysfunction in this system impairs adaptation to cardiac stress, resulting in heart failure.
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| Free Research Field |
循環器内科
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化を背景に、複数臓器の病気を併発している患者が増えている。特に、心腎連関は心不全や慢性腎臓病の治療を難しいものとしている。本研究の成果は、心腎連関の全く新しいメカニズムを明らかにした。また、GM-CSFやAmphiregulin、β受容体等、薬等で介入可能な分子を多数同定した。これらの分子を始めとして、本研究によって同定されたメカニズムは、心腎連関や心不全の治療標的となることが期待できる。
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