2018 Fiscal Year Final Research Report
Elucidation of the mechanism of protective responses induced by a new vaccine with glycolipid against pneumococcal infection
| Project/Area Number |
16H05349
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Jikei University School of Medicine (2018)
National Institute of Infectious Diseases (2016-2017) |
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Principal Investigator |
KINJO Yuki 東京慈恵会医科大学, 医学部, 教授 (20570831)
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| Co-Investigator(Kenkyū-buntansha) |
高塚 翔吾 国立感染症研究所, 真菌部, 研究員 (90609398)
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| Research Collaborator |
Hayashizaki Koji
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 肺炎球菌 / 糖脂質 / ワクチン / 感染防御 / NKT細胞 / 抗体 / 蛋白 / 肺炎 |
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| Outline of Final Research Achievements |
Streptococcus pneumoniae (Pneumococcus) is a bacterium that causes pneumonia and meningitis especially in children and adults aged 65 years and above. Current pneumococcal vaccines are effective. However, in recent years, the serotypes that are not included in the current vaccines are increasing. Therefore, development of new vaccines that provide broad protection against pneumococcal infection is desired.
In this study, we invested the protective effect of a new protein and glycolipid vaccine. Our results indicate that this vaccine induces protective antibody production and long-term protection against pneumococcal infection. Furthermore, we performed immunological analyses to understand the mechanisms of antibody production and elucidated a part of mechanisms of B cell antibody production that is induced with the help of a lymphocyte called as NKT cell.
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| Free Research Field |
感染免疫学，感染症内科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究にて，新規肺炎球菌蛋白・糖脂質ワクチンの接種により，肺炎球菌に結合するIgG抗体の産生および感染防御効果が長期間持続することが明らかになった。また，感染防御効果をもたらす抗体の産生が持続する免疫学的機序の一端を解明することができた。本研究の結果に基づき今後の研究が進展することで，新規肺炎球菌蛋白ワクチンによる抗体産生の持続機構が明らかになるものと考えられる。さらに，その知見を応用することで，有効性の高いワクチンの開発に繋がり，国内のみならず世界中で主な死因の1つになっている肺炎球菌感染症の制御に貢献できる可能性が期待される。
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