Invetigation of pathogensis of SJS/TEN

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H05488
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: SOTOZONO CHIE 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30216585)
• Co-Investigator(Kenkyū-buntansha): 木下 茂 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30116024) ; 上田 真由美 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60398386)
• Research Collaborator: NISHIGAKI HIROMI
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: Stevens-Johnson症候群

Outline of Final Research Achievements

Analysis of lipid mediators of SJS / TEN patients with severe ocular complications showed that there were less glycerine lipids and higher in oxidized PC in the SJS / TEN patients. In proteomics analysis of tears of the SJS / TEN patients, IL-6, IL-8, IFN-g, eotaxin, RANTES, and MIP-1b were elevated in the SJS / TEN patients. In exhaustive protein expression analysis in ocular surface tissues , expression of PIGR, HEPACAM2 and ADH1C decreased significantly and ODZ2 (teneurin-2) increased significantly. In genetic analysis, REC114 and several new related genes were able to identify.

Free Research Field

眼科

Academic Significance and Societal Importance of the Research Achievements

新規の疾患関連遺伝子REC114の発見や、患者組織・細胞や涙液の遺伝子ならびにタンパクの変化の発見は、病態把握につながり、今後の治療方針の決定や、新規治療法の開発に役立つものと期待される