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2018 Fiscal Year Final Research Report

Modulation of lipid homeostasis in maintenance and directed differentiation of mesenchymal stem cells

Research Project

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Project/Area Number 16H05529
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

Inuzuka Hiroyuki  東北大学, 歯学研究科, 准教授 (20335863)

Co-Investigator(Kenkyū-buntansha) 福本 敏  東北大学, 歯学研究科, 教授 (30264253)
齋藤 正寛  東北大学, 歯学研究科, 教授 (40215562)
竹田 浩之  愛媛大学, プロテオサイエンスセンター, 准教授 (40609393)
福島 秀文  東北大学, 歯学研究科, 准教授 (70412624)
Project Period (FY) 2016-04-01 – 2019-03-31
Keywordsタンパク質分解 / 脂質代謝 / Lipin1
Outline of Final Research Achievements

Manipulating lipid biosynthesis in stem cells could be a potential approach for highly efficient directed differentiation of mesenchymal stem cells. In this study, we identified the molecular mechanisms of the proteasome-dependent degradation of Lipin1 that plays critical roles in lipid homeostasis. Our finding will provide insights into the development of novel strategies for the directed differentiation of mesenchymal stem cells through Lipin1 protein stability control.

Free Research Field

医歯薬学

Academic Significance and Societal Importance of the Research Achievements

再生医療研究において間葉系幹細胞の応用が進められているが、幹細胞代謝研究領域での脂質代謝調節に焦点を当てた研究は少ない。薬理学的および遺伝学的アプローチにより脂質合成制御が幹細胞で可能となれば、効率的な細胞分化誘導のほか移植後細胞の脂肪細胞分化転換抑制にも応用可能となることから、本研究で得られた知見は高効率かつ安定的な幹細胞分化誘導法開発の基礎となると期待される。

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Published: 2020-03-30  

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